Journal article
Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent
Tumor biology, v 37(5), pp 6379-6387
May 2016
PMID: 26631034
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Studies of vitamin D-related genetic variants and breast cancer have been inconsistent. This study aimed to investigate associations of vitamin D-related polymorphisms and breast cancer risk among European and East Asian women and potential interactions with menopausal status and breast tumour subtypes. Data from a case–control study of breast cancer (1037 cases and 1050 controls) were used to assess relationships between 21 polymorphisms in two vitamin D-related genes (GC and VDR) and breast cancer risk. Odds ratios were calculated in stratified analyses of European and East Asian women, using logistic regression in an additive genetic model. An interaction term was used to explore modification by menopausal status. Polytomous regression was used to assess heterogeneity by breast tumour subtype. False discovery rate adjustments were conducted to account for multiple testing. No association was observed between GC or VDR polymorphisms and breast cancer risk. Modification of these relationships by menopausal status was observed for select polymorphisms in both Europeans (VDR rs4328262 and rs11168292) and East Asians (GC rs7041 and VDR rs11168287). Heterogeneity by tumour subtype was seen for three VDR polymorphisms (rs1544410, rs7967152 and rs2239186) among Europeans, in which associations with ER−/PR−/HER2+ tumours, but not with other subtypes, were observed. In conclusion, associations between vitamin D-related genetic variants and breast cancer were not observed overall, although the relationships between vitamin D pathway polymorphisms and breast cancer may be modified by menopausal status and breast tumour subtype.
Metrics
Details
- Title
- Genetic variation in vitamin D-related genes and risk of breast cancer among women of European and East Asian descent
- Creators
- Joy Shi - Department of Public Health Sciences and Cancer Research Institute Queen’s University Kingston ON CanadaAnne Grundy - Alberta Cancer Prevention Legacy Fund, Alberta Health Services Calgary AB CanadaHarriet Richardson - Department of Public Health Sciences and Cancer Research Institute Queen’s University Kingston ON CanadaIgor Burstyn - Department of Environmental and Occupational Health Drexel University Philadelphia PA USAJohanna Schuetz - Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency Vancouver BC CanadaCaroline Lohrisch - Department of Medical Oncology, British Columbia Cancer Agency Vancouver BC CanadaSandip SenGupta - Department of Pathology and Molecular Medicine Queen’s University Kingston ON CanadaAgnes Lai - Department of Cancer Control Research, British Columbia Cancer Agency Vancouver BC CanadaAngela Brooks-Wilson - Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby BC CanadaJohn Spinelli - School of Population and Public Health, University of British Columbia Vancouver BC CanadaKristan Aronson - Division of Cancer Care and Epidemiology, Queen’s Cancer Research Institute 10 Stuart Street Kingston ON K7L 3N6 Canada
- Publication Details
- Tumor biology, v 37(5), pp 6379-6387
- Publisher
- Springer Netherlands; Dordrecht
- Grant note
- 69036 / Canadian Institutes of Health Research (http://dx.doi.org/10.13039/501100000024)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000376465800081
- Scopus ID
- 2-s2.0-84948965284
- Other Identifier
- 991014878392704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology