Journal article
Genome-Wide Association Study of Antiphospholipid Antibodies
Autoimmune diseases, v 2013(2013), pp 188-198
01 Jan 2013
PMID: 23509613
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. The persistent presence of antiphospholipid antibodies (APA) may lead to the development of primary or secondary antiphospholipid syndrome. Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown. In this study, we have performed a genome-wide association study (GWAS) in an effort to identify susceptibility loci/genes for three main APA: anticardiolipin antibodies (ACL), lupus anticoagulant (LAC), and anti-beta(2) glycoprotein I antibodies (anti-beta(2) GPI). Methods. DNA samples were genotyped using the Affymetrix 6.0 array containing 906,600 single-nucleotide polymorphisms (SNPs). Association of SNPs with the antibody status (positive/negative) was tested using logistic regression under the additive model. Results. We have identified a number of suggestive novel loci with P < E - 05. Although they do not meet the conservative threshold of genome-wide significance, many of the suggestive loci are potential candidates for the production of APA. We have replicated the previously reported associations of HLA genes and APOH with APA but these were not the top loci. Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings.
Metrics
Details
- Title
- Genome-Wide Association Study of Antiphospholipid Antibodies
- Creators
- M. Ilyas Kamboh - University of PittsburghXingbin Wang - University of PittsburghAmy H. Kao - Allegheny Health NetworkMichael M. Barmada - University of PittsburghAnn Clarke - McGill UniversityRosalind Ramsey-Goldman - Northwestern UniversitySusan Manzi - Allegheny Health NetworkF. Yesim Demirci - University of Pittsburgh
- Publication Details
- Autoimmune diseases, v 2013(2013), pp 188-198
- Publisher
- Hindawi Publishing Group
- Number of pages
- 11
- Grant note
- Lupus Foundation of America HL092397; HL088648; AR057028; AR046588; AR057338; HD066139; AR02318; AR30492; AR48098; AR30692; RR025741 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000219157900025
- Scopus ID
- 2-s2.0-84875647752
- Other Identifier
- 991021934001604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology