Journal article
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
Nature (London), v 419(6906), pp 512-519
03 Oct 2002
PMID: 12368865
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.
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Details
- Title
- Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
- Creators
- Jane M Carlton - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. carlton@tigr.orgSamuel V AngiuoliBernard B SuhTaco W KooijMihaela PerteaJoana C SilvaMaria D ErmolaevaJonathan E AllenJeremy D SelengutHean L KooJeremy D PetersonMihai PopDaniel S KosackMartin F ShumwayShelby L BidwellShamira J ShallomSusan E van AkenSteven B RiedmullerTamara V FeldblyumJennifer K ChoJohn QuackenbushMartha SedegahAzadeh ShoaibiLeda M CummingsLaurence FlorensJohn R YatesJ Dale RaineRobert E SindenMichael A HarrisDeirdre A CunninghamPeter R PreiserLawrence W BergmanAkhil B VaidyaLeo H van LinChris J JanseAndrew P WatersHamilton O SmithOwen R WhiteSteven L SalzbergJ Craig VenterClaire M FraserStephen L HoffmanMalcolm J GardnerDaniel J Carucci
- Publication Details
- Nature (London), v 419(6906), pp 512-519
- Publisher
- Springer Nature; England
- Grant note
- R01 AI028398 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; [Retired Faculty]
- Web of Science ID
- WOS:000178348400046
- Scopus ID
- 2-s2.0-0037015592
- Other Identifier
- 991014877834704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology