Journal article
Genome sequence of the human malaria parasite Plasmodium falciparum
Nature (London), v 419(6906), pp 498-511
03 Oct 2002
PMID: 12368864
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The parasite
Plasmodium falciparum
is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of
P. falciparum
clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host–parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.
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Details
- Title
- Genome sequence of the human malaria parasite Plasmodium falciparum
- Creators
- Malcolm J Gardner - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USANeil Hall - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKEula Fung - Stanford Genome Technology Center, 855 California Avenue, Palo Alto, California 94304, USAOwen White - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAMatthew Berriman - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKRichard W Hyman - Stanford Genome Technology Center, 855 California Avenue, Palo Alto, California 94304, USAJane M Carlton - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAArnab Pain - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKKaren E Nelson - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USASharen Bowman - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKIan T Paulsen - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAKeith James - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKJonathan A Eisen - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAKim Rutherford - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UKSteven L Salzberg - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAAlister Craig - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UKSue Kyes - University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UKMan-Suen Chan - University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UKVishvanath Nene - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAShamira J Shallom - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USABernard Suh - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAJeremy Peterson - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USASam Angiuoli - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAMihaela Pertea - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAJonathan Allen - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAJeremy Selengut - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USADaniel Haft - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAMichael W Mather - Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USAAkhil B Vaidya - Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USADavid M. A Martin - School of Life Sciences, The Wellcome Trust Biocentre, The University of Dundee, Dundee DD1 5EH, UKAlan H Fairlamb - School of Life Sciences, The Wellcome Trust Biocentre, The University of Dundee, Dundee DD1 5EH, UKMartin J Fraunholz - Department of Biology and Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USADavid S Roos - Department of Biology and Genomics Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USAStuart A Ralph - Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Melbourne, VIC 3010, AustraliaGeoffrey I McFadden - Plant Cell Biology Research Centre, School of Botany, University of Melbourne, Melbourne, VIC 3010, AustraliaLeda M Cummings - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USAG. Mani Subramanian - Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USAChris Mungall - Department of Molecular and Cellular Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, California 94720, USAJ. Craig Venter - The Center for the Advancement of Genomics, 1901 Research Boulevard, 6th Floor, Rockville, Maryland 20850, USADaniel J Carucci - Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500, USAStephen L Hoffman - Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500, USAChris Newbold - University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UKRonald W Davis - Stanford Genome Technology Center, 855 California Avenue, Palo Alto, California 94304, USAClaire M Fraser - The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USABart Barrell - The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
- Publication Details
- Nature (London), v 419(6906), pp 498-511
- Publisher
- Springer Nature
- Grant note
- 061524 || WT / Wellcome Trust :
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000178348400045
- Scopus ID
- 2-s2.0-0037015614
- Other Identifier
- 991014877834604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology