Journal article
Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency
Scientific reports, v 14(1), 260
02 Jan 2024
PMID: 38168575
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sleep latency, the amount of time that it takes an individual to fall asleep, is a key indicator of sleep need. Sleep latency varies considerably both among and within species and is heritable, but lacks a comprehensive description of its underlying genetic network. Here we conduct a genome-wide association study of sleep latency. Using previously collected sleep and activity data on a wild-derived population of flies, we calculate sleep latency, confirming significant, heritable genetic variation for this complex trait. We identify 520 polymorphisms in 248 genes contributing to variability in sleep latency. Tests of mutations in 23 candidate genes and additional putative pan-neuronal knockdown of 9 of them implicated CG44153, Piezo, Proc-R and Rbp6 in sleep latency. Two large-effect mutations in the genes Proc-R and Piezo were further confirmed via genetic rescue. This work greatly enhances our understanding of the genetic factors that influence variation in sleep latency.
Metrics
1 Record Views
Details
- Title
- Genome-wide association in Drosophila identifies a role for Piezo and Proc-R in sleep latency
- Creators
- Matthew N. Eiman - National Institutes of HealthShailesh Kumar - National Institutes of HealthYazmin L. Serrano Negron - National Institutes of HealthTerry R. Tansey - National Institutes of HealthSusan T. Harbison - National Institutes of Health
- Publication Details
- Scientific reports, v 14(1), 260
- Publisher
- Nature Publishing
- Number of pages
- 18
- Grant note
- HL006276 / Intramural Research Program of the NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NHLBI Division of Intramural Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Heart Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001163663800117
- Scopus ID
- 2-s2.0-85181230279
- Other Identifier
- 991022202114204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Multidisciplinary Sciences