Journal article
Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
American journal of human genetics, v 95(4), pp 462-471
02 Oct 2014
PMID: 25279986
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 × 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10(-67) to 2.67 × 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [OR(per-allele)] = 1.44; p = 4.59 × 10(-16)) and rs3130437 in HLA class I (OR(per-allele) = 1.23; p = 8.23 × 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
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Details
- Title
- Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
- Creators
- Christine F Skibola - University of Alabama at BirminghamSonja I Berndt - National Institutes of HealthJoseph Vijai - Memorial Sloan Kettering Cancer CenterLucia Conde - University of Alabama at BirminghamZhaoming Wang - National Institutes of HealthMeredith Yeager - Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD 20877, USAPaul I W de Bakker - Utrecht UniversityBrenda M Birmann - Harvard UniversityClaire M Vajdic - UNSW SydneyJia-Nee Foo - Genome Institute of SingaporePaige M Bracci - University of California, San FranciscoRoel C H VermeulenSusan L Slager - Mayo ClinicSilvia de SanjoseSophia S Wang - City Of Hope National Medical CenterMartha S Linet - National Institutes of HealthGilles Salles - Claude Bernard University Lyon 1Qing Lan - National Institutes of HealthGianluca Severi - University of MelbourneHenrik Hjalgrim - Statens Serum InstitutTracy Lightfoot - University of YorkMads Melbye - Stanford UniversityJian Gu - The University of Texas MD Anderson Cancer CenterHervé Ghesquières - French National Centre for Scientific ResearchBrian K Link - University of IowaLindsay M Morton - National Institutes of HealthElizabeth A Holly - University of California, San FranciscoAlex Smith - University of YorkLesley F Tinker - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaLauren R Teras - American Cancer SocietyAnne Kricker - University of SydneyNikolaus Becker - German Cancer Research CenterMark P Purdue - National Institutes of HealthJohn J Spinelli - University of British ColumbiaYawei Zhang - Yale UniversityGraham G Giles - University of MelbournePaolo Vineis - Imperial College LondonAlain Monnereau - University of Paris-SudKimberly A Bertrand - Harvard UniversityDemetrius Albanes - National Institutes of HealthAnne Zeleniuch-Jacquotte - New York UniversityAttilio Gabbas - University of CagliariCharles C Chung - National Institutes of HealthLaurie Burdett - National Institutes of HealthAmy Hutchinson - National Institutes of HealthCharles Lawrence - WestatRebecca Montalvan - WestatLiming Liang - Harvard UniversityJinyan Huang - Harvard UniversityBaoshan Ma - Dalian Maritime UniversityJianjun Liu - Genome Institute of SingaporeHans-Olov Adami - Karolinska InstituteBengt Glimelius - Karolinska InstituteYuanqing Ye - The University of Texas MD Anderson Cancer CenterGrzegorz S Nowakowski - Mayo ClinicAhmet Dogan - Memorial Sloan Kettering Cancer CenterCarrie A Thompson - Mayo ClinicThomas M Habermann - Mayo ClinicAnne J Novak - Mayo ClinicMark Liebow - Mayo ClinicThomas E Witzig - Mayo ClinicGeorge J Weiner - University of IowaMaryjean Schenk - Wayne State UniversityPatricia Hartge - National Institutes of HealthAnneclaire J De Roos - Drexel UniversityWendy Cozen - University of Southern CaliforniaDegui Zhi - University of Alabama at BirminghamNicholas K Akers - University of California, BerkeleyJacques Riby - University of Alabama at BirminghamMartyn T Smith - University of California, BerkeleyMortimer Lacher - Memorial Sloan Kettering Cancer CenterDanylo J Villano - Memorial Sloan Kettering Cancer CenterAnn Maria - Memorial Sloan Kettering Cancer CenterEve Roman - University of YorkEleanor Kane - University of YorkRebecca D Jackson - The Ohio State UniversityKari E North - University of North Carolina at Chapel HillW Ryan Diver - American Cancer SocietyJenny TurnerBruce K Armstrong - University of SydneyYolanda BenaventePaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - International Agency For Research On CancerLenka Foretova - Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, Brno 656 53, Czech RepublicMarc Maynadie - University of BurgundyAnthony Staines - Dublin City UniversityJames McKay - International Agency For Research On CancerAngela R Brooks-Wilson - Simon Fraser UniversityTongzhang Zheng - Yale UniversityTheodore R Holford - Yale UniversitySaioa Chamosa - Health Department, BioDonostia Research Institute, Basque Region 20014, SpainRudolph Kaaks - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg 69120, GermanyRachel S Kelly - Imperial College LondonBodil Ohlsson - Lund UniversityRuth C Travis - University of OxfordElisabete WeiderpassJacqueline Clavel - University of Paris-SudEdward Giovannucci - Harvard UniversityPeter Kraft - Harvard UniversityJarmo Virtamo - Finnish Institute for Health and WelfarePatrizio Mazza - Department of Hematology, Ospedale Nord, Taranto 74100, ItalyPierluigi Cocco - University of CagliariMaria Grazia Ennas - University of CagliariBrian C H Chiu - University of ChicagoJoseph F Fraumeni, Jr - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USAAlexandra Nieters - University of FreiburgKenneth Offit - Memorial Sloan Kettering Cancer CenterXifeng Wu - The University of Texas MD Anderson Cancer CenterJames R Cerhan - Mayo ClinicKarin E Smedby - Karolinska InstituteStephen J Chanock - National Institutes of HealthNathaniel Rothman - National Institutes of Health
- Publication Details
- American journal of human genetics, v 95(4), pp 462-471
- Publisher
- Elsevier
- Grant note
- UL1 TR000142 / NCATS NIH HHS R01 CA154643 / NCI NIH HHS P30 CA033572 / NCI NIH HHS L30 CA162082 / NCI NIH HHS UL1 TR000430 / NCATS NIH HHS P42 ES004705 / NIEHS NIH HHS P30 CA008748 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P30 CA015083 / NCI NIH HHS P50 CA097274 / NCI NIH HHS R01 CA149445 / NCI NIH HHS Intramural NIH HHS P30 CA016672 / NCI NIH HHS P30 ES010126 / NIEHS NIH HHS P30 CA016359 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000342654300011
- Scopus ID
- 2-s2.0-84921517901
- Other Identifier
- 991019168307504721
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- Web of Science research areas
- Genetics & Heredity