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Journal article
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
Nature genetics, v 46(11), pp 1233-1238
01 Nov 2014
PMID: 25261932
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
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- Title
- Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
- Creators
- James R. Cerhan - Mayo ClinicSonja I. Berndt - National Institutes of HealthJoseph Vijai - Memorial Sloan Kettering Cancer CenterHerve Ghesquieres - French National Centre for Scientific ResearchJames McKay - International Agency For Research On CancerSophia S. Wang - City Of Hope National Medical CenterZhaoming Wang - National Institutes of HealthMeredith Yeager - NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USALucia Conde - University of California, BerkeleyPaul I. W. de Bakker - Utrecht UniversityAlexandra Nieters - University of FreiburgDavid Cox - Ctr Leon Berard, Canc Res Ctr Lyon, F-69373 Lyon, FranceLaurie Burdett - National Institutes of HealthAlain Monnereau - INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Environm Epidemiol Canc Grp, Villejuif, FranceChristopher R. Flowers - Emory UniversityAnneclaire J. De Roos - Drexel UniversityAngela R. Brooks-Wilson - Simon Fraser UniversityQing Lan - National Institutes of HealthGianluca Severi - University of MelbourneMads Melbye - Stanford UniversityJian Gu - The University of Texas MD Anderson Cancer CenterRebecca D. Jackson - The Ohio State UniversityEleanor Kane - University of YorkLauren R. Teras - American Cancer SocietyMark P. Purdue - National Institutes of HealthClaire M. Vajdic - UNSW SydneyJohn J. Spinelli - University of British ColumbiaGraham G. Giles - University of MelbourneDemetrius Albanes - National Institutes of HealthRachel S. Kelly - Harvard UniversityMariagrazia Zucca - University of CagliariKimberly A. Bertrand - Harvard UniversityAnne Zeleniuch-Jacquotte - New York UniversityCharles Lawrence - WestatAmy Hutchinson - National Institutes of HealthDegui Zhi - University of Alabama at BirminghamThomas M. Habermann - Mayo ClinicBrian K. Link - University of IowaAnne J. Novak - Mayo ClinicAhmet Dogan - Memorial Sloan Kettering Cancer CenterYan W. Asmann - Mayo ClinicMark Liebow - Mayo ClinicCarrie A. Thompson - Mayo ClinicStephen M. Ansell - Mayo ClinicThomas E. Witzig - Mayo ClinicGeorge J. Weiner - University of IowaAmelie S. Veron - Ctr Leon Berard, Canc Res Ctr Lyon, F-69373 Lyon, FranceDiana Zelenika - Ctr Natl Genotypage, Evry, FranceHerve Tilly - Ctr Henri Becquerel, F-76038 Rouen, FranceCorinne Haioun - CHU Henri Mondor, Dept Hematol, F-94010 Creteil, FranceThierry Jo Molina - University of ParisHenrik Hjalgrim - Statens Serum InstitutBengt Glimelius - Karolinska InstituteHans-Olov Adami - Karolinska InstitutePaige M. Bracci - University of California, San FranciscoJacques Riby - University of California, BerkeleyMartyn T. Smith - University of California, BerkeleyElizabeth A. Holly - University of California, San FranciscoWendy Cozen - University of Southern CaliforniaPatricia Hartge - National Institutes of HealthLindsay M. Morton - National Institutes of HealthRichard K. Severson - Wayne State UniversityLesley F. Tinker - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaKari E. North - University of North Carolina at Chapel HillNikolaus Becker - German Cancer Research CenterYolanda Benavente - Bellvitge Biomed Res Inst IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc UNIC, Barcelona, SpainPaolo Boffetta - Icahn School of Medicine at Mount SinaiPaul Brennan - International Agency For Research On CancerLenka Foretova - Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech RepublicMarc Maynadie - University of BurgundyAnthony Staines - Dublin City UniversityTracy Lightfoot - University of YorkSimon Crouch - University of YorkAlex Smith - University of YorkEve Roman - University of YorkW. Ryan Diver - American Cancer SocietyKenneth Offit - Memorial Sloan Kettering Cancer CenterAndrew Zelenetz - Memorial Sloan Kettering Cancer CenterRobert J. Klein - Memorial Sloan Kettering Cancer CenterDanylo J. Villano - Memorial Sloan Kettering Cancer CenterTongzhang Zheng - Yale UniversityYawei Zhang - Yale UniversityTheodore R. Holford - Yale UniversityAnne Kricker - University of SydneyJenny Turner - Macquarie UniversityMelissa C. Southey - University of MelbourneJacqueline Clavel - INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Environm Epidemiol Canc Grp, Villejuif, FranceJarmo Virtamo - Finnish Institute for Health and WelfareStephanie Weinstein - National Institutes of HealthElio Riboli - Imperial College LondonPaolo Vineis - Statens Serum InstitutRudolph Kaaks - German Cancer Research CenterDimitrios Trichopoulos - Harvard UniversityRoel C. H. Vermeulen - Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, NetherlandsHeiner Boeing - German Inst Human Nutr, Dept Epidemiol, Potsdam, GermanyAnne Tjonneland - Danish Canc Soc, Res Ctr, Copenhagen, DenmarkEmanuele Angelucci - Osped Oncol Riferimento Reg A Businco, Hematol Unit, Cagliari, ItalySimonetta Di Lollo - University of FlorenceMarco Rais - University of CagliariBrenda M. Birmann - Harvard UniversityFrancine Laden - Harvard UniversityEdward Giovannucci - Harvard UniversityPeter Kraft - Harvard UniversityJinyan Huang - Harvard UniversityBaoshan Ma - Dalian Maritime UniversityYuanqing Ye - The University of Texas MD Anderson Cancer CenterBrian C. H. Chiu - University of ChicagoJoshua Sampson - National Institutes of HealthLiming Liang - Harvard UniversityJu-Hyun Park - Dongguk UniversityCharles C. Chung - National Institutes of HealthDennis D. Weisenburger - City Of Hope National Medical CenterNilanjan Chatterjee - National Institutes of HealthJoseph F. Fraumeni - National Institutes of HealthSusan L. Slager - Mayo ClinicXifeng Wu - The University of Texas MD Anderson Cancer CenterSilvia de Sanjose - Bellvitge Biomed Res Inst IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc UNIC, Barcelona, SpainKarin E. Smedby - Karolinska InstituteGilles Salles - Claude Bernard University Lyon 1Christine F. Skibola - University of California, BerkeleyNathaniel Rothman - National Institutes of HealthStephen J. Chanock - National Institutes of Health
- Publication Details
- Nature genetics, v 46(11), pp 1233-1238
- Publisher
- Springer Nature
- Number of pages
- 6
- Grant note
- Intramural Program of the US National Institutes of Health/National Cancer Institute UL1TR000135 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UM1CA167552 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P42ES004705 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) U01HG007033 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000344131900015
- Scopus ID
- 2-s2.0-84908886283
- Other Identifier
- 991019168622304721
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- Genetics & Heredity