Journal article
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
Nature genetics, v 42(9), pp 759-U46
01 Sep 2010
PMID: 20729853
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping 1,077 individuals with ESCC and 1,733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7,673 cases of ESCC and 11,013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified two previously unknown susceptibility loci for ESCC: PLCE1 at 10q23 (P-Han combined (for ESCC) = 7.46 x 10(-56), odds ratio (OR) = 1.43; PUygur-Kazakh for ESCC = 5.70 x 10(-4), OR = 1.53) and C20orf54 at 20p13 (P-Han combined (for ESCC) = 1.21 x 10(-11), OR = 0.86; PUygur-Kazakh for ESCC = 7.88 x 10(-3), OR = 0.66). We also confirmed association in 2,766 cases of gastric cardia adenocarcinoma cases and the same 11,013 control subjects (PLCE1, P-Han for GCA = 1.74 x 10(-39), OR = 1.55 and C20orf54, P-Han for GCA = 3.02 x 10(-3), OR = 0.91). PLCE1 and C20orf54 have important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis. C20orf54 is responsible for transporting riboflavin, and deficiency of riboflavin has been documented as a risk factor for ESCC and GCA.
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Details
- Title
- Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
- Creators
- Li-Dong Wang - Zhengzhou UniversityFu-You Zhou - Zhengzhou UniversityXue-Min Li - Zhengzhou UniversityLiang-Dan Sun - Anhui Medical UniversityXin Song - Zhengzhou UniversityYan Jin - College Station Medical CenterJiang-Man Li - Zhengzhou UniversityGuo-Qiang Kong - Zhengzhou UniversityHong Qi - Zhengzhou UniversityJuan Cui - Zhengzhou UniversityLian-Qun Zhang - College Station Medical CenterJie-Zhi Yang - Zhengzhou UniversityJi-Lin Li - Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R ChinaXing-Chuan Li - Zhengzhou UniversityJing-Li Ren - Zhengzhou UniversityZhi-Cai Liu - Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R ChinaWen-Jun Gao - College Station Medical CenterLing Yuan - Zhengzhou UniversityWu Wei - College Station Medical CenterYan-Rui Zhang - Henan Prov Peoples Hosp, Dept Gastroenterol, Zhengzhou, Henan, Peoples R ChinaWei-Peng Wang - Zhengzhou UniversityIlyar Sheyhidin - Xinjiang Medical UniversityFeng Li - Shihezi UniversityBao-Ping Chen - Henan UniversityShu-Wei Ren - Xinyang Cent Hosp, Dept Oncol, Xinyang, Henan, Peoples R ChinaBin Liu - Capital Medical UniversityDan Li - Zhengzhou UniversityJian-Wei Ku - College Station Medical CenterZong-Min Fan - Zhengzhou UniversitySheng-Li Zhou - College Station Medical CenterZhi-Gang Guo - College Station Medical CenterXue-Ke Zhao - College Station Medical CenterNa Liu - College Station Medical CenterYong-Hong Ai - College Station Medical CenterFang-Fang Shen - College Station Medical CenterWen-Yan Cui - College Station Medical CenterShuang Song - Zhengzhou UniversityTao Guo - Zhengzhou UniversityJing Huang - Zhengzhou UniversityChao Yuan - Zhengzhou UniversityJia Huang - Zhengzhou UniversityYue Wu - Zhengzhou UniversityWen-Bin Yue - Peoples Hosp Puyang, Dept Oncol, Puyang, Henan, Peoples R ChinaChang-Wei Feng - Zhengzhou UniversityHong-Lei Li - Zhengzhou UniversityYan Wang - Zhengzhou UniversityJin-Ya Tian - Zhengzhou UniversityYue Lu - Zhengzhou UniversityYi Yuan - College Station Medical CenterWen-Liang Zhu - Zhengzhou UniversityMin Liu - Zhengzhou UniversityWen-Jing Fu - Zhengzhou UniversityXia Yang - Zhengzhou UniversityHan-Jing Wang - Zhengzhou UniversitySuo-Li Han - Zhengzhou UniversityJie Chen - Zhengzhou UniversityMin Han - First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Henan, Peoples R ChinaHai-Yan Wang - College Station Medical CenterPeng Zhang - College Station Medical CenterXiu-Min Li - College Station Medical CenterJin-Cheng Dong - Zhengzhou UniversityGuo-Lan Xing - Zhengzhou UniversityRan Wang - Zhengzhou UniversityMing Guo - Zhengzhou UniversityZhi-Wei Chang - Zhengzhou UniversityHai-Lin Liu - College Station Medical CenterLi Guo - Zhengzhou UniversityZhi-Qing Yuan - College Station Medical CenterHai Liu - Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming, Yunnan, Peoples R ChinaQin Lu - Zhengzhou UniversityLiu-Qin Yang - Cent Hosp Xinxiang, Dept Radiotherapy, Xinxiang, Henan, Peoples R ChinaFu-Guo Zhu - First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu, Henan, Peoples R ChinaXiu-Feng Yang - Hebi Dahejian Hosp, Dept Surg, Hebi, Henan, Peoples R ChinaXiao-Shan Feng - Henan University of Science and TechnologyZhou Wang - Shandong UniversityYin Li - Canc Hosp Henan Prov, Dept Thorac Surg & Radiotherapy, Zhengzhou, Henan, Peoples R ChinaShe-Gan Gao - Henan UniversityQirenwang Qige - Inner Mongolia Medical UniversityLong-Tang Bai - Inner Mongolia Medical UniversityWen-Jun Yang - College Station Medical CenterGuang-Yan Lei - Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian, Shaanxi, Peoples R ChinaZhong-Ying Shen - Shantou UniversityLong-Qi Chen - Sichuan UniversityEn-Min Li - Shantou UniversityLi-Yan Xu - Shantou UniversityZhi-Yong Wu - Shantou UniversityWei-Ke Cao - Nanjing Medical UniversityJian-Po Wang - Zhengzhou UniversityZhi-Qin Bao - Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R ChinaJi-Li Chen - Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R ChinaGuang-Cheng Ding - Zhengzhou UniversityXiang Zhuang - Zhengzhou UniversityYing-Fa Zhou - Zhengzhou UniversityHou-Feng Zheng - Anhui Medical UniversityZheng Zhang - Anhui Medical UniversityXian-Bo Zuo - Anhui Medical UniversityZi-Ming Dong - Zhengzhou UniversityDong-Mei Fan - Zhengzhou UniversityXin He - Zhengzhou UniversityJin Wang - Zhengzhou UniversityQi Zhou - Zhengzhou UniversityQin-Xian Zhang - Zhengzhou UniversityXin-Ying Jiao - Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R ChinaShi-Yong Lian - Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou, Henan, Peoples R ChinaAi-Fang Ji - College Station Medical CenterXiao-Mei Lu - Xinjiang Medical UniversityJin-Sheng Wang - Zhengzhou UniversityFu-Bao Chang - College Station Medical CenterChang-Dong Lu - Anyang Tumor Hosp, Dept Thorac Surg & Tumor Prevent Treatment, Anyang, Henan, Peoples R ChinaZhi-Guo Chen - College Station Medical CenterJian-Jun Miao - Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R ChinaZeng-Lin Fan - Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian, Hebei, Peoples R ChinaRuo-Bai Lin - College Station Medical CenterTai-Jiang Liu - Red Cross Hosp Huojia, Dept Surg, Xinxiang, Henan, Peoples R ChinaJin-Chang Wei - Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou, Henan, Peoples R ChinaQing-Peng Kong - Kunming Institute of ZoologyYu Lan - Beijing Jishuitan HospitalYu-Jing Fan - Beijing Jishuitan HospitalFu-Sheng Gao - Capital Medical UniversityTian-Yun Wang - College Station Medical CenterDong Xie - Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R ChinaShu-Qing Chen - Zhejiang UniversityWan-Cai Yang - University of Illinois ChicagoJun-Yan Hong - Zhejiang UniversityLiang Wang - College Station Medical CenterSong-Liang Qiu - Zhengzhou UniversityZhi-Ming Cai - Peking UniversityXue-Jun Zhang - Anhui Medical University
- Publication Details
- Nature genetics, v 42(9), pp 759-U46
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- 2009-5 / Xinxiang Medical University 30670956; 30971133 / National Natural Science Foundations; National Natural Science Foundation of China (NSFC) 2008-7 / Education Department of Henan Province 2007-7 / Anhui Provincial Special Scientific Program 2009-8 / Science and Technology Department of Henan Province 2009-10 / Health Department of Henan Province 2007CB516812 / China Key Program on Basic Research 2006AA02A403; 2007AA02Z161 / 863 HighTech Key Projects; National High Technology Research and Development Program of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Urban Health Collaborative; Drexel University
- Web of Science ID
- WOS:000281388400010
- Scopus ID
- 2-s2.0-77956626748
- Other Identifier
- 991020099542204721
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- Domestic collaboration
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- Genetics & Heredity