Journal article
Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast
Molecular human reproduction, v 14(3), pp 143-150
Mar 2008
PMID: 18250106
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cutlet/CTF18 encodes an evolutionarily conserved protein that is crucial for germline development in Drosophila melanogaster. Loss of function of cutlet in the fly results in a sterile phenotype due to the failure of germline stem cells to proliferate. CTF18 was first identified in Saccharomyces cerevisiae as a sister chromatid cohesion factor that is essential for the faithful transmission of chromosomes during DNA replication. We have cloned and characterized the human and mouse CTF18 orthologs of the D. melanogaster gene, cutlet. We have demonstrated that CTF18 mRNA is expressed in human and mouse testis and ovary, and that CTF18 protein is expressed throughout the male and female germline of the mouse. We suggest a unique biological role for CTF18 in mammalian germ cell development based on its mammalian germline expression, high degree of evolutionary conservation, and role in DNA replication and chromosomal stability in yeast.
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Details
- Title
- Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast
- Creators
- Karen M. Berkowitz - University of PennsylvaniaKlaus H. Kaestner - University of PennsylvaniaThomas A. Jongens - University of Pennsylvania
- Publication Details
- Molecular human reproduction, v 14(3), pp 143-150
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; College of Medicine; Drexel University; Obstetrics and Gynecology
- Web of Science ID
- WOS:000257148700002
- Scopus ID
- 2-s2.0-40949143556
- Other Identifier
- 991020100210904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Developmental Biology
- Obstetrics & Gynecology
- Reproductive Biology