Journal article
Gestational Age and Autism Spectrum Disorder: Trends in Risk Over Time
Autism research, v 9(2), pp 224-231
Feb 2016
PMID: 26363410
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder. Several previous studies have identified preterm birth as a risk factor for ASD but none has studied whether the association between gestational age and ASD has changed over time. This is a Danish population-based follow-up study including live-born singletons born in Denmark between 1980 and 2009, identified in the Danish Medical Birth Registry, a study population of 1,775,397 children. We used a Cox regression model combined with spline to study the risk for ASD by gestational age across three decades of birth cohorts. We included 19,020 children diagnosed with ASD. Across all birth year cohorts, we found that the risk of being diagnosed with ASD increased with lower gestational age (P-value: <0.01). Across all gestational weeks, we found a statistically significant higher risk estimates in birth cohort 1980 to 1989, compared to birth cohorts 1990 to 1999 and 2000 to 2009, respectively. No statistically significant difference in risk estimates was observed between birth cohort 1990 to 1999 and 2000 to 2009. The observed time trend in risk of ASD after preterm birth may reflect: (1) a change in the risk profile of persons with ASD due to the broadening of ASD diagnostic criteria over time; or (2) improved neonatal care for low GA infants, which has reduced risk of adverse outcomes like ASD in preterm children. Autism Res2016, 9: 224-231. (c) 2015 International Society for Autism Research, Wiley Periodicals, Inc.
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Details
- Title
- Gestational Age and Autism Spectrum Disorder: Trends in Risk Over Time
- Creators
- H. O. Atladottir - Aarhus UniversityD. E. Schendel - Aarhus UniversityT. B. Henriksen - Aarhus University HospitalL. Hjort - Aarhus University HospitalE. T. Parner - Aarhus University
- Publication Details
- Autism research, v 9(2), pp 224-231
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Aarhus University Research Foundation R155-2014-1724 / Lundbeck Foundation; Lundbeckfonden Aase and Ejnar Danielsens Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000371484900006
- Scopus ID
- 2-s2.0-84958590432
- Other Identifier
- 991021463554304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Behavioral Sciences
- Psychology, Developmental