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Journal article
Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies
International journal of environmental research and public health, v 18(3), pp 1-17
01 Feb 2021
PMID: 33573264
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Linear regression is often used to estimate associations between chemical exposures and neurodevelopment at the mean of the outcome. However, the potential effect of chemicals may be greater among individuals at the 'tails' of outcome distributions. Here, we investigated distributional effects on the associations between gestational phthalate exposure and child Autism Spectrum Disorder (ASD)-related behaviors using quantile regression. We harmonized data from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 140) Study, an enriched-risk cohort of mothers who had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study (n = 276), a general population cohort. We measured concentrations of 9 phthalate metabolites in urine samples collected twice during pregnancy. Caregivers reported children's ASD-related behaviors using the Social Responsiveness Scale (SRS) at age 3-8 years; higher scores indicate more ASD-related behaviors. In EARLI, associations between phthalate concentrations and SRS scores were predominately inverse or null across SRS score quantiles. In HOME, positive associations of mono-n-butyl phthalate, monobenzyl phthalate, mono-isobutyl phthalate, and di-2-ethylhexyl phthalate concentrations with SRS scores increased in strength from the median to 95th percentile of SRS scores. These results suggest associations between phthalate concentrations and SRS scores may be stronger in individuals with higher SRS scores.
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Details
- Title
- Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies
- Creators
- Marisa A. Patti - Brown UniversityCraig Newschaffer - Drexel UniversityMelissa Eliot - Brown UniversityGhassan B. Hamra - Johns Hopkins UniversityAimin Chen - University of PennsylvaniaLisa A. Croen - Kaiser PermanenteM. Daniele Fallin - Johns Hopkins UniversityIrva Hertz-Picciotto - University of California, DavisGeetika Kalloo - AdaCoreJane C. Khoury - Cincinnati Children's Hospital Medical CenterBruce P. Lanphear - Simon Fraser UniversityKristen Lyall - Drexel UniversityKimberly Yolton - Cincinnati Children's Hospital Medical CenterJoseph M. Braun - Brown University
- Publication Details
- International journal of environmental research and public health, v 18(3), pp 1-17
- Publisher
- Mdpi
- Number of pages
- 17
- Grant note
- R01 ES026903; R01 ES016443; R01 ES024381; R01 ES020349; R01 ES011261; R01 ES014575 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000615153900001
- Scopus ID
- 2-s2.0-85100010263
- Other Identifier
- 991019168163504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health