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Journal article
Glial localization of adenylate-cyclase-coupled β-adrenoreceptors in rat forebrain slices
Brain research, v 530(2), pp 295-300
1990
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Abstract
Fluorocitrate (FC), a selective inhibitor of glial cell respiration, was used to estimate the extent to which glial cells contain adenylate cyclase-coupled β-adrenoreceptors in rat brain slices. The drug blocked 75–95% of the elevation of cyclic AMP caused by the β-agonist, isoproterenol, in the 4 forebrain regions sampled (frontal and parietal cortex, caudate nucleus, olfactory tubercle). Intracellular recording of neurons in the treated slices confirmed that they were unaffected by FC. Treatment with the neurotoxin, kainic acid, eliminated all electrophysiological activity but did not affect the cAMP response. The results indicate that glial cells contain the preponderance of adenylate-cyclase-coupled β-adrenoreceptors in slices of the rat forebrain and may constitute an important target of the central noradrenergic system in vivo.
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Details
- Title
- Glial localization of adenylate-cyclase-coupled β-adrenoreceptors in rat forebrain slices
- Creators
- Eric A. Stone - New York UniversityFrancis M. Sessler - Hahnemann University HospitalLiu Weimin - Hahnemann University Hospital
- Publication Details
- Brain research, v 530(2), pp 295-300
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1990EH60300017
- Scopus ID
- 2-s2.0-0025089234
- Other Identifier
- 991019184037904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences