Journal article
Glioneuronal Phenotype in a Diencephalic Pilomyxoid Astrocytoma
Pediatric and developmental pathology, v 9(6), pp 480-487
Nov 2006
PMID: 17163791
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report the presence of divergent populations of cells in a hypothalamic/chiasmatic pilomyxoid astrocytoma of an 11-month-old male, exhibiting differential immunohistochemical localizations for glial fibrillary acidic protein (GFAP) and synaptophysin. The tumor cells were negative for Neu-N and neurofilament protein. Ultrastructurally, the tumor comprised 2 cell types, one with features attributable to a neuronal phenotype alongside cells exhibiting an overt astroglial phenotype. This composite organization was confirmed by confocal microscopy, which revealed 2 distinct, albeit tightly interwoven, populations of GFAP and synaptophysin-labeled tumor cells. Our results indicate that a subset of the so-called pilomyxoid astrocytomas of the hypothalamic/chiasmatic region may represent phenotypically mixed glioneuronal neoplasms distinct from the pilocytic astrocytomas.
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Details
- Title
- Glioneuronal Phenotype in a Diencephalic Pilomyxoid Astrocytoma
- Creators
- Jean-Pierre de Chadarévian - St. Christopher's Hospital for ChildrenGregory E. Halligan - St. Christopher's Hospital for ChildrenGoutham Reddy - St. Christopher's Hospital for ChildrenLouise Bertrand - Drexel UniversityJudy M. Pascasio - St. Christopher's Hospital for ChildrenEric N. Faerber - St. Christopher's Hospital for ChildrenChristos D. Katsetos - St. Christopher's Hospital for Children
- Publication Details
- Pediatric and developmental pathology, v 9(6), pp 480-487
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000248596200008
- Scopus ID
- 2-s2.0-33845938503
- Other Identifier
- 991019169652804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pathology
- Pediatrics