Files and links (1)
https://findresearcher.sdu.dk/ws/files/175307984/Borja_2020_Global_brain_glucose_uptake_on_18F_FDG_PETCT_is_influenced.pdf
SubmittedOpen Access (License Unspecified), Open
Journal article
Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk
NUCLEAR MEDICINE COMMUNICATIONS, v 42(4), pp 444-450
Apr 2021
PMID: 33323870
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose The goal of this study was to assess global cerebral glucose uptake in subjects with known cardiovascular risk factors by employing a quantitative F-18-fluorodeoxyglucose-PET/computed tomography (FDG-PET/CT) technique. We hypothesized that at-risk subjects would demonstrate decreased global brain glucose uptake compared to healthy controls. Methods We compared 35 healthy male controls and 14 male subjects at increased risk for cardiovascular disease (CVD) as assessed by the systematic coronary risk evaluation (SCORE) tool. All subjects were grouped into two age-matched cohorts: younger (<50 years) and older (>= 50 years). The global standardized uptake value mean (Avg SUVmean) was measured by mapping regions of interest of the entire brain across the supratentorial structures and cerebellum. Wilcoxon's rank-sum test was used to assess the differences in Avg SUVmean between controls and at-risk subjects. Results Younger subjects demonstrated higher brain Avg SUVmean than older subjects. In addition, in both age strata, the 10-year risk for fatal CVD according to the SCORE tool was significantly greater in the at-risk groups than in healthy controls (younger: P = 0.0304; older: P = 0.0436). In the younger cohort, at-risk subjects demonstrated significantly lower brain Avg SUVmean than healthy controls (P = 0.0355). In the older cohort, at-risk subjects similarly had lower Avg SUVmean than controls (P = 0.0343). Conclusions Global brain glucose uptake appears to be influenced by chronic cardiovascular risk factors. Therefore, FDG-PET/CT may play a role in determining the importance of CVD on brain function and has potential for monitoring the efficacy of various therapeutic interventions.
Metrics
Details
- Title
- Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk
- Publication Details
- NUCLEAR MEDICINE COMMUNICATIONS, v 42(4), pp 444-450
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS; PHILADELPHIA
- Number of pages
- 6
- Grant note
- We thank the staff and participants of the CAMONA research study for their contributions. The Jorgen and Gisela Thrane's Philanthropic Research Foundation, Broager, Denmark, financially supported the CAMONA study. They played no role in the actual study.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000639304900014
- Scopus ID
- 2-s2.0-85102910350
- Other Identifier
- 991021860662304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging