Journal article
Glucagon: Prehospital therapy for hypoglycemia
Annals of emergency medicine, v 20(4), pp 375-379
01 Apr 1991
PMID: 2003665
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Abstract
This study evaluated the efficacy of glucagon for prehospital therapy of hypoglycemia in patients without IV access.
Prospective clinical trial.
Prehospital in a busy, urban emergency medical services system.
Fifty consecutive patients presenting with documented hypoglycemia (ChemStrip BG
® < 80 mg/dL) and symptoms of decreased level of consciousness, syncope, or seizure were enrolled.
Data collected included pretreatment (ChemStrip BG
®) and post-treatment serum glucose (hospital assay) as well as assessment of level of consciousness by a quantitative measure, the Glasgow Coma Score, and by a qualitative scale (0 to 3). The mean pretreatment blood glucose of 33.2 ± 23.3 mg/dL increased after treatment to 133.3 ± 57.3 mg/dL. Qualitative level of consciousness increased from a mean of 1.26 ± .96 to 2.42 ± .94 and Glasgow Coma Score increased from a mean of 9.0 ± 4.19 to 13.04 ± 3.68. The mean time until response was 8.8 minutes in those who responded to both level of consciousness criteria 82% (41 of 50). Glucagon administered for hypoglycemia resulted in a glucose increase in 98% (49 of 50) with headache as the only side effect noted in 4% (two of 50) of patients (P < .0001).
Glucagon is safe and effective therapy for hypoglycemia in the prehospital setting.
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Details
- Title
- Glucagon: Prehospital therapy for hypoglycemia
- Creators
- Rade B Vukmir - Harvard Affiliated Emergency Medicine ResidencyPaul M Paris - University of PittsburghDonald M Yealy - EMERGENCY
- Publication Details
- Annals of emergency medicine, v 20(4), pp 375-379
- Publisher
- Mosby, Inc
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1991FD80400010
- Scopus ID
- 2-s2.0-0026101117
- Other Identifier
- 991021903399804721
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- Web of Science research areas
- Emergency Medicine