Journal article
Glucose oxidase multilayer modified microcantilevers for glucose measurement
Analytical chemistry (Washington), v 77(19), pp 6197-6204
01 Oct 2005
PMID: 16194079
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report a novel enzyme-based microcantilever sensor by using layer-by-layer nanoassembly modification. A glucose oxidase (GOx) functionalized microcantilever underwent bending when it was exposed to glucose solutions. The magnitudes of bending were proportional to the concentrations of glucose. The cantilever bending was specific toward glucose, but not to other sugars such as mannose, fructose, or galactose. The flow rate effect on the cantilever bending response is also discussed. The bending mechanism was investigated, and the kinetic and thermodynamic analysis and experimental results showed that the conformational change of GOx and gluconic formation were the origin of cantilever deflection.
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Details
- Title
- Glucose oxidase multilayer modified microcantilevers for glucose measurement
- Creators
- Xiaodong Yan - Department of Chemistry, Institute for Micromanufacturing, Louisiana Tech University, Ruston, Louisiana 71272, USAXiaohe Karen XuHai-Feng Ji
- Publication Details
- Analytical chemistry (Washington), v 77(19), pp 6197-6204
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000232443700025
- Scopus ID
- 2-s2.0-26444448542
- Other Identifier
- 991014878437604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical