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Journal article
Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) Detects Effects of Transcranial Magnetic Stimulation to the Motor Cortex
NeuroImage (Orlando, Fla.), v 256, 119191
01 Aug 2022
PMID: 35413447
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transcranial magnetic stimulation (TMS) is used in several FDA-approved treatments and, increasingly, to treat neurological disorders in off-label uses. However, the mechanism by which TMS causes physiological change is unclear, as are the origins of response variability in the general population. Ideally, objective in vivo biomarkers could shed light on these unknowns and eventually inform personalized interventions. Continuous theta-burst stimulation (cTBS) is a form of TMS observed to reduce motor evoked potentials (MEPs) for 60 min or longer post-stimulation, although the consistency of this effect and its mechanism continue to be under debate. Here, we use glutamate-weighted chemical exchange saturation transfer (gluCEST) magnetic resonance imaging (MRI) at ultra-high magnetic field (7T) to measure changes in glutamate concentration at the site of cTBS. We find that the gluCEST signal in the ipsilateral hemisphere of the brain generally decreases in response to cTBS, whereas consistent changes were not detected in the contralateral region of interest (ROI) or in subjects receiving sham stimulation.
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Details
- Title
- Glutamate-Weighted Magnetic Resonance Imaging (GluCEST) Detects Effects of Transcranial Magnetic Stimulation to the Motor Cortex
- Creators
- Abigail T.J. Cember - Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: cember@pennmedicine.upenn.edu.Benjamin L. Deck - Drexel UniversityApoorva Kelkar - Drexel UniversityOlu Faseyitan - University of PennsylvaniaJared P. Zimmerman - University of PennsylvaniaBrian Erickson - Drexel UniversityMark A. Elliott - University of PennsylvaniaH. Branch Coslett - University of PennsylvaniaRoy H. Hamilton - University of PennsylvaniaRavinder Reddy - University of PennsylvaniaJohn D. Medaglia - Drexel University
- Publication Details
- NeuroImage (Orlando, Fla.), v 256, 119191
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000830364700001
- Scopus ID
- 2-s2.0-85130176693
- Other Identifier
- 991019169562604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging