Journal article
Glutamatergic systems in neuropathic pain and emerging non-opioid therapies
Pharmacological research, v 185, pp 106492-106492
01 Nov 2022
PMID: 36228868
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuropathic pain, a disease of the somatosensory nervous system, afflicts many individuals and adequate management with current pharmacotherapies remains elusive. The glutamatergic system of neurons, receptors and transporters are intimately involved in pain but, to date, there have been few drugs developed that therapeutically modulate this system. Glutamate transporters, or excitatory amino acid transporters (EAATs), remove excess glutamate around pain transmitting neurons to decrease nociception suggesting that the modulation of glutamate transporters may represent a novel approach to the treatment of pain. This review highlights and summarizes (1) the physiology of the glutamatergic system in neuropathic pain, (2) the preclinical evidence for dysregulation of glutamate transport in animal pain models, and (3) emerging novel therapies that modulate glutamate transporters. Successful drug discovery requires continuous focus on basic and translational methods to fully elucidate the etiologies of this disease to enable the development of targeted therapies. Increasing the efficacy of astrocytic EAATs may serve as a new way to successfully treat those suffering from this devastating disease.
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Details
- Title
- Glutamatergic systems in neuropathic pain and emerging non-opioid therapies
- Creators
- Rhea Temmermand - Drexel UniversityJames E. Barrett - Temple UniversityAndreia C. K. Fontana - Drexel Univ, Dept Pharmacol & Physiol, Coll Med, Philadelphia, PA 19102 USA
- Publication Details
- Pharmacological research, v 185, pp 106492-106492
- Publisher
- Elsevier
- Number of pages
- 32
- Grant note
- NS111767 / NINDS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 2022-G-5 / AANA Foundation Grant DA047700 / NIDA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology; Neurology
- Web of Science ID
- WOS:000872120100005
- Scopus ID
- 2-s2.0-85139726393
- Other Identifier
- 991020099208604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy