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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Glycosylation and liver cancer
Advances in cancer research, v 126, pp 257-279
2015
PMID: 25727150
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Liver cancer is the fifth most common cancer, but the second leading cause of cancer death, in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is infection with an hepatotropic virus such as hepatitis B virus or hepatitis C virus infection. While chronic viral infection remains the main cause of liver disease and risk of hepatocellular carcinoma (HCC), rates of nonviral-associated HCC are occurring at an alarmingly increasing rate. Like many cancers, survival rates are closely associated with time of detection. If HCC is caught early, survival rates can be as high as 50%. Regrettably, most cases of HCC are caught late where survival rates can be as low as 2-7%. Thus, there has been great interest in discovering serum biomarkers that could be used to identify those with HCC. To this end, many groups have examined the N-linked glycans to identify changes that occur with HCC. As the liver secretes the vast majority of proteins into the serum, this has often been a starting point for study. In serum, alterations in core fucosylation, outer-arm fucosylation, increased sialylation, and glycan branching have been observed in patients with HCC. Similar findings have been found directly in HCC tissue suggesting that these glycan changes may play a role in tumor formation and development.
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Details
- Title
- Glycosylation and liver cancer
- Creators
- Anand Mehta - Drexel UniversityHarmin Herrera - Drexel UniversityTimothy Block - Drexel University
- Publication Details
- Advances in cancer research, v 126, pp 257-279
- Publisher
- Elsevier
- Grant note
- U01 CA168856 / NCI NIH HHS R01 CA120206 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000385011800008
- Scopus ID
- 2-s2.0-84923518201
- Other Identifier
- 0128016140; 9780128016145; 991019167607804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Oncology