Journal article
GnRH agonists: gonadorelin, leuprolide and nafarelin
American family physician, v 44(5), pp 1777-1782
Nov 1991
PMID: 1835275
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Gonadotropin-releasing hormone (GnRH), a decapeptide synthesized and released by the hypothalamus, regulates production and release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the adenohypophysis. Parenterally administered GnRH was initially used diagnostically as a test of adenohypophyseal reserve of LH and FSH. Subsequently, native GnRH was used therapeutically to treat hypothalamic hypogonadal and infertility states in both men and women. Because of the low potency and short half-life of native GnRH, long-acting, potent analogs have been developed that suppress secretion of native pituitary gonadotropins, resulting in medical gonadectomy. When administered parenterally and, more recently, intranasally, these compounds are useful in the management of prostate and breast carcinoma, endometriosis and uterine leiomyomata, precocious puberty and nontumorous ovarian hyperandrogenic syndromes.
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Details
- Title
- GnRH agonists: gonadorelin, leuprolide and nafarelin
- Creators
- J N Pace - Hahnemann University School of Medicine, Philadelphia, PennsylvaniaJ L MillerL I Rose
- Publication Details
- American family physician, v 44(5), pp 1777-1782
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Management
- Web of Science ID
- WOS:A1991GQ61800025
- Scopus ID
- 2-s2.0-0025837427
- Other Identifier
- 991019184303704721
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- Web of Science research areas
- Primary Health Care