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Grand challenges for systems neuroscience: perspectives and opportunities
Journal article   Open access   Peer reviewed

Grand challenges for systems neuroscience: perspectives and opportunities

Wen-Jun Gao
Frontiers in systems neuroscience, v 20, 1818506
07 Apr 2026
PMID: 42021836
Featured in Collection :   Drexel's Newest Publications
url
https://doi.org/10.3389/fnsys.2026.1818506View
Published, Version of Record (VoR) Open CC BY V4.0

Abstract

big data grand challenge new era perspective systems neuroscience
Systems neuroscience seeks to uncover how diverse neuronal populations and distributed neural types, circuits, and regions in the brain give rise to perception, learning, emotion, cognition, and behavior, and how dysfunction at any of these levels contributes to neurological and psychiatric disorders. The field has rapidly expanded from single-cell studies to large-scale, multimodal interrogation and manipulation of brain-wide activity, creating unprecedented opportunities alongside major conceptual and technical challenges. Systems neuroscience is at a pivotal moment, with advances in basic, translational, and clinical research converging to deepen understanding of how neural activity generates mental life.

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