Journal article
Granulocyte-macrophage colony-stimulating factor as adjuvant therapy for interferon α treatment of chronic hepatitis c
Cytokine (Philadelphia, Pa.), v 8(4), pp 318-322
1996
PMID: 9162222
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The safety and efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) as adjuvant therapy for interferon α (IFN-α) treatment has been evaluated in 20 non-cirrhotic patients with chronic hepatitis C virus (HCV) infection. Adjuvant therapy with GM-CSF plus IFN-α was associated with less myelosuppression than with IFN-α alone (
P< .01), although the rate of local adverse reactions increased. GM-CSF adjuvant therapy led to a 50% biochemical response (transaminase values within the normal range at therapy end) and to reductions in HCV RNA concentrations (median HCV RNA reduction of 99%, range 8–100%), which were similarly observed in single IFN-α recipients (median HCV RNA reduction of 91%, range 38–100%). However, HCV RNA became undetectable in three biochemical responders to the GM-CSF adjuvant therapy, but in only one biochemical non-responder to IFN-αalone. The use of GM-CSF as adjuvant therapy is safe and, although it has not improved the biochemical response, it might potentiate the virologic response to IFN-α treatment alone.
Metrics
Details
- Title
- Granulocyte-macrophage colony-stimulating factor as adjuvant therapy for interferon α treatment of chronic hepatitis c
- Creators
- Vicente Carreño - Fundación para el Estudio de las Hepatitis ViralesVicente Carreño - Fundación para el Estudio de las Hepatitis ViralesAdolfo Parra - Hospital Universitario Fundación Jiménez DíazSonia Navas-Martin - Drexel University, Microbiology and ImmunologyAntonio Juan Quiroga - Fundación para el Estudio de las Hepatitis Virales
- Publication Details
- Cytokine (Philadelphia, Pa.), v 8(4), pp 318-322
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1996UF85000008
- Scopus ID
- 2-s2.0-0029927669
- Other Identifier
- 991022047819104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology