Journal article
Graphene-Based Materials for the Fast Removal of Cytokines from Blood Plasma
ACS applied bio materials, v 1(2), pp 436-443
20 Aug 2018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is a range of medical conditions, which include acute organ failure, bacterial and viral infection, and sepsis, that result in overactivation of the inflammatory response of the organism and release of proinflammatory cytokines into the bloodstream. Fast removal of these cytokines from blood circulation could offer a potentially efficient treatment of such conditions. This study aims at the development and assessment of novel biocompatible graphene-based adsorbents for blood purification from proinflammatory cytokines. These graphene-based materials were chosen on the basis of their surface accessibility for small molecules further facilitated by the interlayer porosity, which is comparable to the size of the cytokine molecules to be adsorbed. Our preliminary results show that graphene nanoplatelets (GnP) exhibit high adsorption capacity, but they cannot be used in direct contact with blood due to the risk of small carbon particle release into the bloodstream. Granulation of GnP using poly(tetrafluoroethylene) as a binder eliminated an undesirable nanoparticle release without affecting the GnP surface accessibility for the cytokine molecules. The efficiency of proinflammatory cytokine removal was shown using a specially designed flow-through system. So far, GnP proved to be among the fastest acting and most efficient sorbents for cytokine removal identified to date, outperforming porous activated carbons and porous polymers.
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Details
- Title
- Graphene-Based Materials for the Fast Removal of Cytokines from Blood Plasma
- Creators
- Mykola Seredych - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials InstituteBernard Haines - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials InstituteViktoriia Sokolova - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials InstitutePaul Cheung - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials InstituteFayan Meng - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials InstituteLon Stone - Consultants RxLyuba Mikhalovska - University of BrightonSergey Mikhalovsky - University of BrightonVadym N Mochalin - Missouri University of Science & TechnologyYury Gogotsi - Department of Materials Science & Engineering and A.J. Drexel Nanomaterials Institute
- Publication Details
- ACS applied bio materials, v 1(2), pp 436-443
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Chemistry
- Web of Science ID
- WOS:000615983400025
- Scopus ID
- 2-s2.0-85070559835
- Other Identifier
- 991014970143704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology