Journal article
Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling
The Journal of cell biology, v 177(1)
09 Apr 2007
PMCID: PMC2064116
PMID: 17420293
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Amajor function of the endocytic system is the sorting of cargo to various organelles. Endocytic sorting of the yeast reductive iron transporter, which is composed of the Fet3 and Ftr1 proteins, is regulated by available iron. When iron is provided to iron-starved cells, Fet3p–Ftr1p is targeted to the lysosome-like vacuole and degraded. In contrast, when iron is not available, Fet3p–Ftr1p is maintained on the plasma membrane via an endocytic recycling pathway requiring the sorting nexin Grd19/Snx3p, the pentameric retromer complex, and the Ypt6p Golgi Rab GTPase module. A recycling signal in Ftr1p was identified and found to bind directly to Grd19/Snx3p. Retromer and Grd19/Snx3p partially colocalize to tubular endosomes, where they are physically associated. After export from the endosome, Fet3p–Ftr1p transits through the Golgi apparatus for resecretion. Thus, Grd19/Snx3p, functions as a cargo-specific adapter for the retromer complex, establishing a precedent for a mechanism by which sorting nexins expand the repertoire of retromer-dependent cargos.
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Details
- Title
- Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling
- Creators
- Todd I. Strochlic - University of PennsylvaniaThanuja Gangi Setty - University of PennsylvaniaAnand Sitaram - University of PennsylvaniaChristopher G. Burd - University of Pennsylvania
- Publication Details
- The Journal of cell biology, v 177(1)
- Publisher
- The Rockefeller University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000245587600011
- Scopus ID
- 2-s2.0-34247143246
- Other Identifier
- 991020837831104721
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- Web of Science research areas
- Cell Biology