Journal article
Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults
Journal of the American Heart Association, v 9(9), pp e015697-e015697
05 May 2020
PMID: 32340506
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background
Epidemiological data suggest a link between psychological stress and increased cardiovascular disease risk; however, the underlying mechanisms remain incompletely understood. The purpose of this investigation was to directly examine the influence of daily psychosocial stress on microvascular adrenergic vasoconstrictor responsiveness in healthy adults. We hypothesized increased daily psychosocial stress would be positively related to increased norepinephrine-induced vasoconstriction.
Methods and Results
Eighteen healthy adults (19-36 years; 10 women) completed a daily psychosocial experiences telephone interview for 8 consecutive evenings in order to document their exposure and emotional responsiveness to common stressors (eg, arguments, work stress) over the preceding 24 hrs. On the last interview day, red cell flux (laser Doppler flowmetry) was measured during graded intradermal microdialysis perfusion of norepinephrine (10(-12) to 10(-2) mol/L) and expressed as a percentage of baseline vascular conductance. Exogenous norepinephrine elicited progressive and robust vasoconstriction in all individuals (maximal vasoconstriction: 71 +/- 4%(base); cumulative vasoconstriction [area under the curve]: 118 +/- 102 arbitrary units). Participants experienced a stressor on 51 +/- 5% of days and a total of 5.2 +/- 0.9 stressors over the 8-day time frame. Increased daily frequency of stressor exposure was positively related to both maximal (R-2=0.26; P=0.03) and cumulative (R-2=0.31; P=0.02) vasoconstrictor responsiveness. Likewise, the total number of stressors was associated with increased maximal (R-2=0.40; P<0.01) and cumulative (R-2=0.27; P=0.03) norepinephrine-induced vasoconstriction. Neither stressor severity nor stress-related emotions were related to vasoconstrictor responsiveness.
Conclusions
Collectively, these data suggest that daily psychosocial stressor exposure by itself is sufficient to adversely influence microvascular vasoconstrictor function, regardless of the perceived severity or emotional consequences of the stressor exposure.
Metrics
Details
- Title
- Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults
- Creators
- Jody L. Greaney - The University of Texas at ArlingtonAgus Surachman - Pennsylvania State UniversityErika F. H. Saunders - Penn State Milton S. Hershey Medical CenterLacy M. Alexander - Pennsylvania State UniversityDavid M. Almeida - Pennsylvania State University
- Publication Details
- Journal of the American Heart Association, v 9(9), pp e015697-e015697
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Penn State Social Science Research Institute UL1 TR002014 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) HL133414; T32 AG049676 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dana and David Dornsife School of Public Health; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000538145600008
- Scopus ID
- 2-s2.0-85084272003
- Other Identifier
- 991021448037204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems