Journal article
Growth hormone response to desmethylimipramine in depressed and suicidal adolescents
Journal of affective disorders, v 15(3), pp 323-337
01 Nov 1988
PMID: 2975304
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Abstract
Desipramine 75 mg i.m. was given in the morning to 20 adolescents with major depressive disorder and 23 normal controls. Depressed adolescents secreted significantly less growth hormone (GH) over the next 2 h than did normal adolescents, although a substantial proportion of the differences were accounted for by the depressed adolescents who had a specific suicidal plan or attempt during the episode. Severity of depression or the presence of other depressive symptoms did not predict GH secretion within the depressed group. Age, sex and maturational factors in the control of GH are discussed. It is concluded that these differences in GH secretion probably reflect differences in CNS β-adrenergic and/or serotonergic function. Suicidality and depression may have different psychobiological correlates in adolescents.
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Details
- Title
- Growth hormone response to desmethylimipramine in depressed and suicidal adolescents
- Creators
- Neal D. Ryan - Columbia UniversityJoaquim Puig-Antich - Columbia UniversityHarris Rabinovich - Columbia UniversityPaul Ambrosini - Columbia UniversityDelbert Robinson - Columbia UniversityBeverly Nelson - Columbia UniversityHana Novacenko - Columbia University
- Publication Details
- Journal of affective disorders, v 15(3), pp 323-337
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry; [Retired Faculty]
- Web of Science ID
- WOS:A1988Q973300012
- Scopus ID
- 2-s2.0-0023798580
- Other Identifier
- 991021895759504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Psychiatry