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Journal article
Guanfacine alters the effect of stress and smoking on heart rate variability in regular daily smokers
PSYCHOPHARMACOLOGY, v 234(5), pp 805-813
01 Mar 2017
PMID: 28028603
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We had previously demonstrated that guanfacine, an alpha 2a-adrenergic agonist, attenuated the effect of stress on smoking-lapse behavior in regular daily smokers. Heart rate variability (HRV), a measure of vagal activity, may be a potential mechanism underlying the relationship between stress, smoking, and relapse.
We examined whether guanfacine (0 mg/day vs. 3 mg/day; n = 26) altered changes in high-frequency heart rate variability (HF-HRV) following stress and ad-lib smoking using a validated laboratory analogue of smoking-lapse behavior. All participants completed a parent study evaluating the effects of guanfacine on stress-precipitated smoking. Each subject completed two laboratory sessions assessing the effects of guanfacine on HF-HRV following stress imagery (vs. neutral imagery; order counterbalanced) and smoking.
Results demonstrated that guanfacine did not increase tonic levels of HF-HRV relative to placebo. Following the stress versus neutral imagery manipulation (prior to ad-lib smoking), there were no significant changes in HF-HRV in the placebo group. In contrast, guanfacine increased phasic HF-HRV following stress imagery and decreased HF-HRV following neutral imagery. Ad libitum smoking following both the stress and neutral conditions decreased HF-HRV in the placebo group across both imagery conditions. In contrast, guanfacine attenuated stress- and smoking-related decreases in phasic HF-HRV relative to the neutral imagery condition.
This is the first demonstration that a noradrenergic target altered dynamic changes in HF-HRV in response to stress and smoking, suggesting that guanfacine alters HF-HRV response to stress. Findings support current theories which suggest that phasic changes in HRV are an important marker of the stress response.
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Details
- Title
- Guanfacine alters the effect of stress and smoking on heart rate variability in regular daily smokers
- Creators
- Terril L. Verplaetse - Yale UniversityPhilip H. Smith - CUNY School of LawKathryn M. Z. Smith - Columbia UniversityLindsay M. Oberleitner - Yale UniversitySherry A. McKee - Yale University
- Publication Details
- PSYCHOPHARMACOLOGY, v 234(5), pp 805-813
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- T32DA007238 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission CTSA-pUL1RR024139 / Yale UL1RR024139 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01AA022285 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) T32DA007238 / National Institute on Drug Abuse (NIDA); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) P50DA033945; R01DA035001; R01AA022285; RL1DA024857 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR001863 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000394498200007
- Scopus ID
- 2-s2.0-85007416141
- Other Identifier
- 991022031022904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry