Journal article
HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts
Cell death and differentiation, v 20(12), pp 1675-1687
01 Dec 2013
PMID: 24037088
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific microRNAs (miRNAs); however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genome-wide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs). Interestingly, several hypoxia-upregulated T-UCRs, henceforth named 'hypoxia-induced noncoding ultraconserved transcripts' (HINCUTs), are also overexpressed in clinical samples from colon cancer patients. We show that these T-UCRs are predominantly nuclear and that the hypoxia-inducible factor (HIF) is at least partly responsible for the induction of several members of this group. One specific HINCUT, uc.475 (or HINCUT-1) is part of a retained intron of the host protein-coding gene, O-linked N-acetylglucosamine transferase, which is overexpressed in epithelial cancer types. Consistent with the hypothesis that T-UCRs have important function in tumor formation, HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. Our data gives a first glimpse of a novel functional hypoxic network comprising protein-coding transcripts and noncoding RNAs (ncRNAs) from the T-UCRs category.
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Details
- Title
- HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts
- Creators
- J. Ferdin - The University of Texas MD Anderson Cancer CenterN. Nishida - Osaka UniversityX. Wu - Indiana University-PurdueM. S. Nicoloso - The University of Texas at AustinM. Y. Shah - The University of Texas at AustinC. Devlin - Indiana University-PurdueH. Ling - The University of Texas at AustinM. Shimizu - The University of Texas at AustinK. Kumar - Indiana University-PurdueM. A. Cortez - The University of Texas at AustinM. Ferracin - Laboratory for Technologies of Advanced Therapies (LTTA)Y. Bi - The Wistar InstituteD. Yang - The University of Texas MD Anderson Cancer CenterB. Czerniak - The University of Texas MD Anderson Cancer CenterW. Zhang - The University of Texas MD Anderson Cancer CenterT. D. Schmittgen - The Ohio State UniversityM. P. Voorhoeve - National University of SingaporeM. J. Reginato - Drexel UniversityM. Negrini - Laboratory for Technologies of Advanced Therapies (LTTA)R. V. Davuluri - The Wistar InstituteT. Kunej - University of LjubljanaM. Ivan - Indiana University-PurdueG. A. Calin - The University of Texas at Austin
- Publication Details
- Cell death and differentiation, v 20(12), pp 1675-1687
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- SINF MDACC_DKFZ grant in CLL R01CA135444 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Fellow at The University of Texas RGK Foundation CA135444; R01 CA155332-01A1 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Department of Defense Breast Cancer Idea Award; United States Department of Defense Estate of CG Johnson P4-0220; 30767 / Slovenian Research Agency (ARRS); Slovenian Research Agency - Slovenia MD Anderson Research Trust P50 CA097007; P50 CA100632 / Developmental Research Award CLL Global Research Foundation Laura and John Arnold Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000327010600011
- Scopus ID
- 2-s2.0-84887620047
- Other Identifier
- 991019169568704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology