Files and links (2)
Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
HIV-1 DNA vaccines and chemokines
Vaccine, v 17(2), pp S53-S64
1999
PMID: 10506409
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
DNA vaccines have a demonstrated ability to induce humoral and cellular immune responses in animal models and humans. The technology, although it dates back to the 1950's, has had an insurgence of interest within the past few years following concurrent research papers. The basic technology is being applied broadly to viral, bacterial and parasitic infections. It has also been demonstrated that genes delivered via plasmid expression vectors result in expression of functional proteins in the inoculated host. Further, injection of plasmids encoding cytokine, chemokine or co-stimulatory molecules, also referred to as immunomodulatory plasmids can lead to the further expansion of this technology to include directed immunology. We have been developing DNA technology specifically with a focus as a vaccine against HIV-1 infection. We report that such vaccines can stimulate immune responses in a variety of relevant animal systems including humoral and cellular responses as well as the production of β-chemokines. We describe that the β-chemokines can both modulate the immune response induced by DNA vaccines and be modulated by the DNA vaccines in the murine and chimpanzee models as well as in humans.
Metrics
Details
- Title
- HIV-1 DNA vaccines and chemokines
- Creators
- Jean D. Boyer - University of PennsylvaniaJong Kim - University of PennsylvaniaKen Ugen - USF, College of Medicine, Tampa, FL, USAAdam D. Cohen - University of PennsylvaniaLois Ahn - University of PennsylvaniaKristen Schumann - University of PennsylvaniaKim Lacy - Hospital of the University of PennsylvaniaMark L. Bagarazzi - Hahnemann University HospitalAli Javadian - Coulston Foundation, Alamagordo, NM, USARichard B. Ciccarelli - WLVP Inc, Malvern, PA, USARichard S. Ginsberg - WLVP Inc, Malvern, PA, USARob Roy MacGregor - Hospital of the University of PennsylvaniaDavid B. Weiner - University of PennsylvaniaJinWon Kim - Chemical and Biological Engineering
- Publication Details
- Vaccine, v 17(2), pp S53-S64
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000082901500008
- Scopus ID
- 2-s2.0-0033215528
- Other Identifier
- 991019168165604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental