Journal article
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity
PloS one, v 11(4), pp e0150835-e0150835
2016
PMID: 27100290
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity. This study presents a cross-sectional/longitudinal study of HIV-1 single nucleotide polymorphisms (SNPs) contained within the viral promoter or long terminal repeat (LTR) in patients within the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. HIV-1 LTR SNPs were found to associate with the classical clinical disease parameters CD4+ T-cell count and log viral load. They were found in both defined and undefined transcription factor binding sites of the LTR. A novel SNP identified at position 108 in a known COUP (chicken ovalbumin upstream promoter)/AP1 transcription factor binding site was significantly correlated with binding phenotypes that are potentially the underlying cause of the associated clinical outcome (increase in viral load and decrease in CD4+ T-cell count).
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Details
- Title
- HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity
- Creators
- Michael R Nonnemacher - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaVanessa Pirrone - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaRui Feng - Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of AmericaBrian Moldover - B-Tech Consulting, Ltd., Philadelphia, Pennsylvania, United States of AmericaShendra Passic - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaBenjamas Aiamkitsumrit - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaWill Dampier - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaAdam Wojno - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaEvelyn Kilareski - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaBrandon Blakey - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaTse-Sheun Jade Ku - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaSonia Shah - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaNeil T Sullivan - Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaJeffrey M Jacobson - Division of Infectious Disease and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaBrian Wigdahl - Center for Clinical and Translational Medicine, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America
- Publication Details
- PloS one, v 11(4), pp e0150835-e0150835
- Publisher
- Public LIbrary of Science (PLOS); United States
- Grant note
- DA19807 / NIDA NIH HHS R01 DA019807 / NIDA NIH HHS NS46263 / NINDS NIH HHS R01 NS032092 / NINDS NIH HHS 5T32MH079785 / NIMH NIH HHS NS32092 / NINDS NIH HHS R01 NS046263 / NINDS NIH HHS T32 MH079785 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000374898500004
- Scopus ID
- 2-s2.0-84964614310
- Other Identifier
- 991014878024304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology