Journal article
HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination
PLoS pathogens, v 4(12), pp e1000215-e1000215
Dec 2008
PMID: 19112504
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patients with HIV-1 often present with a wide range of hematopoietic abnormalities, some of which may be due to the presence of opportunistic infections and to therapeutic drug treatments. However, many of these abnormalities are directly related to HIV-1 replication in the bone marrow (BM). Although the most primitive hematopoietic progenitor cells (HPCs) are resistant to HIV-1 infection, once these cells begin to differentiate and become committed HPCs they become increasingly susceptible to HIV-1 infection and permissive to viral gene expression and infectious virus production. Trafficking of BM-derived HIV-1-infected monocytes has been shown to be involved in the dissemination of HIV-1 into the central nervous system (CNS), and it is possible that HIV-1 replication in the BM and infection of BM HPCs may be involved in the early steps leading to the development of HIV-1-associated dementia (HAD) as an end result of this cellular trafficking process. In addition, the growth and development of HPCs in the BM of patients with HIV-1 has also been shown to be impaired due to the presence of HIV-1 proteins and changes in the cytokine milieu, potentially leading to an altered maturation process and to increased cell death within one or more BM cell lineages. Changes in the growth and differentiation process of HPCs may be involved in the generation of monocyte populations that are more susceptible and/or permissive to HIV-1, and have potentially altered trafficking profiles to several organs, including the CNS. A monocyte subpopulation with these features has been shown to expand during the course of HIV-1 disease, particularly in HAD patients, and is characterized by low CD14 expression and the presence of cell surface CD16.
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Details
- Title
- HIV-1 infection of bone marrow hematopoietic progenitor cells and their role in trafficking and viral dissemination
- Creators
- Aikaterini Alexaki - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USABrian Wigdahl
- Publication Details
- PLoS pathogens, v 4(12), pp e1000215-e1000215
- Publisher
- Public LIbrary of Science (PLOS); United States
- Grant note
- DA19807 / NIDA NIH HHS R01 DA019807 / NIDA NIH HHS NS32092 / NINDS NIH HHS NS46263 / NINDS NIH HHS R01 NS046263 / NINDS NIH HHS R01 NS032092 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000263927500001
- Scopus ID
- 2-s2.0-58149261687
- Other Identifier
- 991014877659504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Microbiology
- Parasitology
- Virology