Journal article
HIV-1 populations in blood and breast milk are similar
Virology (New York, N.Y.), v 330(1), pp 295-303
05 Dec 2004
PMID: 15527854
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1) through breast milk is a significant mechanism of infection in many regions of the world. We compared the HIV-1 populations in paired blood and breast milk samples using a heteroduplex tracking assay (HTA) for the V1/V2 regions of
env (V1/V2-HTA). V1/V2-HTA patterns were similar in the eight pairs of samples for which adequate template sampling could be demonstrated. No unique variants existed in either compartment, and differences detected in the relative abundance of variants between compartments were small, occurred among low abundance variants, and were not statistically significant. We also documented the impact of template sampling as a limiting feature in comparing two viral populations. The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated.
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Details
- Title
- HIV-1 populations in blood and breast milk are similar
- Creators
- Gavin J. Henderson - University of North Carolina at Chapel HillNoah G. Hoffman - University of North Carolina at Chapel HillLi Hua Ping - University of North Carolina at Chapel HillSusan A. Fiscus - University of North Carolina at Chapel HillIrving F. Hoffman - University of North Carolina at Chapel HillKathryn M. Kitrinos - University of North Carolina at Chapel HillTopia Banda - Kamuzu Central HospitalFrancis E.A. Martinson - University of North Carolina at Chapel HillPeter N. Kazembe - Kamuzu Central HospitalDavid A. Chilongozi - University of North Carolina at Chapel HillMyron S. Cohen - University of North Carolina at Chapel HillRonald Swanstrom - University of North Carolina at Chapel Hill
- Publication Details
- Virology (New York, N.Y.), v 330(1), pp 295-303
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:000225195600027
- Scopus ID
- 2-s2.0-7444222859
- Other Identifier
- 991021838282304721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Virology