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Journal article
HIV-associated cellular senescence: A contributor to accelerated aging
Ageing research reviews, v 36, pp 117-124
01 Jul 2017
PMID: 28017881
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Due to the advent of antiretroviral therapy HIV is no longer a terminal disease and the HIV infected patients are becoming increasingly older. While this is a major success, with increasing age comes an increased risk for disease. The age-related comorbidities that HIV infected patients experience suggest that they suffer from accelerated aging. One possible contributor to this accelerated aging is cellular senescence, an age-associated response that can occur prematurely in response to stress, and that is emerging as a contributor to disease and aging. HIV patients experience several stressors such as the virus itself, antiretroviral drugs and to a lesser extent, substance abuse that can induce cellular senescence. This review summarizes the current knowledge of senescence induction in response to these stressors and their relation to the comorbidities in HIV patients. Cellular senescence may be a possible therapeutic target for these comorbidities. (C) 2016 Elsevier B.V. All rights reserved.
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Details
- Title
- HIV-associated cellular senescence: A contributor to accelerated aging
- Creators
- Justin Cohen - Drexel UniversityClaudio Torres - Drexel University
- Publication Details
- Ageing research reviews, v 36, pp 117-124
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- 1RO1NS078283; NS78283; R21AG046943 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21MH097623 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01NS078283 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R21AG046943 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000402947400011
- Scopus ID
- 2-s2.0-85017562243
- Other Identifier
- 991019168242604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology