Journal article
HIV envelope binding by macrophage-expressed gp340 promotes HIV-1 infection
The Journal of immunology (1950), v 181(3), pp 2065-2070
01 Aug 2008
PMID: 18641344
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The scavenger receptor cysteine-rich protein gp340 functions as part of the host innate immune defense system at mucosal surfaces. In the genital tract, its expression by cervical and vaginal epithelial cells promotes HIV trans-infection and may play a role in sexual transmission. Gp340 is an alternatively spliced product of the deleted in malignant brain tumors 1 (DMBT1) gene. In addition to its innate immune system activity, DMBT1 demonstrates instability in multiple types of cancer and plays a role in epithelial cell differentiation. We demonstrate that monocyte-derived macrophages express gp340 and that HIV-1 infection is decreased when envelope cannot bind it. Inhibition of infection occurred at the level of fusion of M-, T-, and dual-tropic envelopes. Additional HIV-1 envelope binding molecules, such as dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), mannose-binding lectin, and heparan sulfate, enhance the efficiency of infection of the cells that express them by increasing the local concentration of infectious virus. Our data suggest that gp340, which is expressed by macrophages in vivo, may function to enhance infection in much the same manner. Its expression on tissue macrophages and epithelial cells suggests important new opportunities for HIV-1 pathogenesis investigation and therapy.
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Details
- Title
- HIV envelope binding by macrophage-expressed gp340 promotes HIV-1 infection
- Creators
- Georgetta Cannon - Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAYanjie YiHouping NiEarl StoddardDavid A ScalesDonald I Van RykIrwin ChaikenDaniel MalamudDrew Weissman
- Publication Details
- The Journal of immunology (1950), v 181(3), pp 2065-2070
- Publisher
- American Association of Immunologists (AAI); United States
- Grant note
- HL620600 / NHLBI NIH HHS R01 AI060505-04 / NIAID NIH HHS R01 AI060505-02 / NIAID NIH HHS R01 DE012930-03 / NIDCR NIH HHS R01 AI060505-03 / NIAID NIH HHS R01 AI060505-05 / NIAID NIH HHS R01 DE012930-02 / NIDCR NIH HHS R01 AI060505-01A1 / NIAID NIH HHS DE12930 / NIDCR NIH HHS R01 DE012930-01 / NIDCR NIH HHS R01 AI060505 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000257898100053
- Scopus ID
- 2-s2.0-49649095419
- Other Identifier
- 991014877825504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology