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Accepted (AM)Open Access (License Unspecified), Open
Journal article
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Nature medicine, v 15(8), pp 893-U92
01 Aug 2009
PMCID: PMC2859814
PMID: 19543283
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV persists in a reservoir of latently infected CD4(+) T cells in individuals treated with highly active antiretroviral therapy (HAART). Here we identify central memory (T-CM) and transitional memory (T-TM) CD4(+) T cells as the major cellular reservoirs for HIV and find that viral persistence is ensured by two different mechanisms. HIV primarily persists in T-CM cells in subjects showing reconstitution of the CD4(+) compartment upon HAART. This reservoir is maintained through T cell survival and low-level antigen-driven proliferation and is slowly depleted with time. In contrast, proviral DNA is preferentially detected in T-TM cells from aviremic individuals with low CD4(+) counts and higher amounts of interleukin-7-mediated homeostatic proliferation, a mechanism that ensures the persistence of these cells. Our results suggest that viral eradication might be achieved through the combined use of strategic interventions targeting viral replication and, as in cancer, drugs that interfere with the self renewal and persistence of proliferating memory T cells. (C) 2009 Nature America, Inc. All rights reserved.
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Details
- Title
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
- Creators
- Nicolas Chomont - Université de MontréalMohamed El-Far - Université de MontréalPetronela Ancuta - Université de MontréalLydie Trautmann - Université de MontréalFrancesco A. Procopio - Université de MontréalBader Yassine-Diab - Université de MontréalGenevieve Boucher - Université de MontréalMohamed-Rachid Boulassel - McGill UniversityGeorges Ghattas - McGill UniversityJason M. Brenchley - National Institutes of HealthTimothy W. Schacker - University of MinnesotaBrenna J. Hill - National Institutes of HealthDaniel C. Douek - National Institutes of HealthJean-Pierre Routy - McGill UniversityElias K. Haddad - CR CHUM St Luc, Immunol Lab, Montreal, PQ, CanadaRafick-Pierre Sekaly - Université de Montréal
- Publication Details
- Nature medicine, v 15(8), pp 893-U92
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- ZIAAI001029 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Z99 AI999999 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine); Drexel University
- Web of Science ID
- WOS:000268770400033
- Scopus ID
- 2-s2.0-68349139711
- Other Identifier
- 991020099054204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental