Journal article
HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
The Journal of immunology (1950), v 172(7), pp 4444-4453
01 Apr 2004
PMID: 15034060
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human immunodeficiency virus-specific CD8(+) T cells are highly sensitive to spontaneous and CD95/Fas-induced apoptosis, and this sensitivity may impair their ability to control HIV infection. To elucidate the mechanism behind this sensitivity, in this study we examined the levels of antiapoptotic molecules Bcl-2 and Bcl-x(L) in HIV-specific CD8(+) T cells from HIV-infected individuals. Bcl-2 expression was markedly decreased in HIV-specific CD8(+) T cells compared with CMV-specific and total CD8(+) T cells from HIV-infected individuals as well as total CD8(+) T cells from healthy donors. CD8(+) T cell Bcl-2 levels inversely correlated with spontaneous and CD95/Fas-induced apoptosis of CD8(+) T cells from HIV-infected individuals. HIV-specific CD8(+) T cells also had significantly lower levels of Bcl-x(L) compared with CMV-specific CD8(+) T cells. Finally, IL-15 induces both Bcl-2 and Bcl-x(L) expression in HIV-specific and total CD8(+) T cells, and this correlated with apoptosis inhibition and increased survival in both short- and long-term cultures. Our data indicate that reduced Bcl-2 and Bcl-x(L) may play an important role in the increased sensitivity to apoptosis of HIV-specific CD8(+) T cells and suggest a possible mechanism by which IL-15 increases their survival.
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Details
- Title
- HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL
- Creators
- Constantinos Petrovas - Drexel UniversityYvonne M Mueller - * Microbiology and Immunology andIoannis D Dimitriou - * Microbiology and Immunology andPaul M Bojczuk - * Microbiology and Immunology andKaram C Mounzer - Philadelphia FightJames Witek - Drexel UniversityJohn D Altman - Emory UniversityPeter D Katsikis - * Microbiology and Immunology and
- Publication Details
- The Journal of immunology (1950), v 172(7), pp 4444-4453
- Publisher
- American Association of Immunologists (AAI)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000222072900053
- Scopus ID
- 2-s2.0-1642289250
- Other Identifier
- 991019348752704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology