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Journal article
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC
Nature communications, v 14(1), pp 575-575
02 Feb 2023
PMID: 36732510
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of an effective vaccine to protect against HIV acquisition will be greatly bolstered by in-depth understanding of the innate and adaptive responses to vaccination. We report here that the efficacy of DNA/ALVAC/gp120/alum vaccines, based on V2-specific antibodies mediating apoptosis of infected cells (V2-ADCC), is complemented by efferocytosis, a cyclic AMP (cAMP)-dependent antiphlogistic engulfment of apoptotic cells by CD14
monocytes. Central to vaccine efficacy is the engagement of the CCL2/CCR2 axis and tolerogenic dendritic cells producing IL-10 (DC-10). Epigenetic reprogramming in CD14
cells of the cyclic AMP/CREB pathway and increased systemic levels of miRNA-139-5p, a negative regulator of expression of the cAMP-specific phosphodiesterase PDE4D, correlated with vaccine efficacy. These data posit that efferocytosis, through the prompt and effective removal of apoptotic infected cells, contributes to vaccine efficacy by decreasing inflammation and maintaining tissue homeostasis.
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Details
- Title
- HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC
- Creators
- Massimiliano Bissa - National Cancer InstituteSohyoung Kim - National Institutes of HealthVeronica Galli - National Cancer InstituteSlim Fourati - Emory UniversitySarkis Sarkis - National Cancer InstituteAnush Arakelyan - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentIsabela Silva de Castro - National Cancer InstituteMohammad Arif Rahman - National Cancer InstituteSaori Fujiwara - National Institutes of HealthMonica Vaccari - Tulane UniversityJeffrey A Tomalka - Emory UniversityJames D Stamos - National Cancer InstituteLuca Schifanella - National Cancer InstituteGiacomo Gorini - National Cancer InstituteRamona Moles - National Cancer InstituteAnna Gutowska - National Cancer InstituteGuido Ferrari - Duke University School of MedicineAlexei Lobanov - National Cancer InstituteDavid C Montefiori - Duke University School of MedicineGeorge W Nelson - National Cancer InstituteMargaret C Cam - National Cancer InstituteElias K Haddad - Drexel UniversityMelvin N Doster - National Cancer InstituteKatherine McKinnon - National Cancer InstituteSophia Brown - National Cancer InstituteDavid J Venzon - National Cancer InstituteHyoyoung Choo-Wosoba - National Cancer InstituteMatthew W Breed - Frederick National Laboratory for Cancer ResearchKristin E Killoran - Frederick National Laboratory for Cancer ResearchJoshua Kramer - Frederick National Laboratory for Cancer ResearchLeonid Margolis - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentRafick P Sekaly - Emory UniversityGordon L Hager - National Institutes of HealthGenoveffa Franchini - National Cancer Institute
- Publication Details
- Nature communications, v 14(1), pp 575-575
- Publisher
- Springer Nature
- Grant note
- P30 AI050409 / NIAID NIH HHS HHSN272201800004C / NIAID NIH HHS P30 AI064518 / NIAID NIH HHS P51 OD011104 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:001076389000009
- Scopus ID
- 2-s2.0-85147318859
- Other Identifier
- 991020111492204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology