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Journal article
HIV virion capturing liposomes for therapeutic vaccination
Biomaterials, v 331, 124124
Aug 2026
PMID: 41830767
Abstract
HIV infection currently has no effective cures and requires lifelong antiretroviral treatments. Cures have failed due to HIV's immune evasion and rapid mutation rate. Here we present a first in class HIV therapeutic vaccine, termed nanotrap therapeutic vaccines (NTVs) that are designed to capture circulating HIV virions and facilitate internalization by local antigen presenting cells. NTVs are modified liposomes that display the CD4 mimetic molecule, CJF288, on their surfaces and have the TLR 7/8 agonist R848 loaded into their bilayer. We show that NTVs can 1) bind gp120 and capture pseudoviral particles, 2) facilitate uptake by antigen presenting cells and 3) generate robust anti-HIV CD8 T cell immunity in transient infection mouse models. NTVs have translational potential to generate patient-specific HIV immunity.
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Details
- Title
- HIV virion capturing liposomes for therapeutic vaccination
- Creators
- Keunsil Kang - Drexel University, Chemical and Biological EngineeringCharles G Ang - Drexel University, Biochemistry and Molecular BiologyGabriela A Canziani - Drexel University, Biochemistry and Molecular BiologyHeba Elkateb - Drexel University, Chemical and Biological EngineeringDivine Hannah Thomas - Drexel University, School of Biomedical Engineering, Science, and Health SystemsDerek Yang - University of PennsylvaniaAmos B Smith III - University of PennsylvaniaElias El Haddad - Drexel University, Infectious Diseases (and HIV Medicine)Irwin M Chaiken - Drexel University, Biochemistry and Molecular BiologyPeter E Deak (Corresponding Author) - Drexel University, Chemical and Biological Engineering
- Publication Details
- Biomaterials, v 331, 124124
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- NIH (NIAID): 1R56AI179226-01 EKH
Funding for this project was provided by the NIH (NIAID) 1R56AI179226-01 to PD, IC and EKH.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; School of Biomedical Engineering, Science, and Health Systems; Infectious Diseases (and HIV Medicine); Chemical and Biological Engineering
- Web of Science ID
- WOS:001719540400001
- Scopus ID
- 2-s2.0-105033861856
- Other Identifier
- 991022165739904721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials