Journal article
HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites
Global health action, v 7(1), pp 25370-25370
01 Jan 2014
PMID: 25377330
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data.
Objective: To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia.
Design: Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population.
Results: The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates.
Conclusions: Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.
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Details
- Title
- HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites
- Creators
- P. Kim Streatfield - International Centre for Diarrhoeal Disease ResearchWasif A. Khan - International Centre for Diarrhoeal Disease ResearchAbbas Bhuiya - International Centre for Diarrhoeal Disease ResearchSyed M. A. Hanifi - International Centre for Diarrhoeal Disease ResearchNurul Alam - International Centre for Diarrhoeal Disease ResearchOurohire Millogo - INDEPTH Network, POB KD213, Kanda, Accra, GhanaAli Sie - Indepth NetworkPascal Zabre - INDEPTH Network, POB KD213, Kanda, Accra, GhanaClementine Rossier - Indepth NetworkAbdramane B. Soura - Indepth NetworkBassirou Bonfoh - Indepth NetworkSiaka Kone - Indepth NetworkEliezer K. Ngoran - INDEPTH Network, POB KD213, Kanda, Accra, GhanaJuerg Utzinger - Swiss Tropical and Public Health InstituteSemaw F. Abera - University of BahrainYohannes A. Melaku - University of BahrainBerhe Weldearegawi - University of BahrainPierre Gomez - Medical Research CouncilMomodou Jasseh - Medical Research CouncilPatrick Ansah - Indepth NetworkDaniel Azongo - INDEPTH Network, POB KD213, Kanda, Accra, GhanaFelix Kondayire - INDEPTH Network, POB KD213, Kanda, Accra, GhanaAbraham Oduro - Indepth NetworkAlberta Amu - INDEPTH Network, POB KD213, Kanda, Accra, GhanaMargaret Gyapong - Indepth NetworkOdette Kwarteng - INDEPTH Network, POB KD213, Kanda, Accra, GhanaShashi Kant - All India Institute of Medical SciencesChandrakant S. Pandav - All India Institute of Medical SciencesSanjay K. Rai - All India Institute of Medical SciencesSanjay Juvekar - Indepth NetworkVeena Muralidharan - INDEPTH Network, POB KD213, Kanda, Accra, GhanaAbdul Wahab - Universitas Gadjah MadaSiswanto Wilopo - Universitas Gadjah MadaEvasius Bauni - Wellcome TrustGeorge Mochamah - Wellcome TrustCarolyne Ndila - Wellcome TrustThomas N. Williams - Imperial College LondonSammy Khagayi - Kenya Medical Research InstituteKayla F. Laserson - Kenya Medical Research InstituteAmek Nyaguara - Kenya Medical Research InstituteAnna M. Van Eijk - Kenya Medical Research InstituteAlex Ezeh - Indepth NetworkCatherine Kyobutungi - INDEPTH Network, POB KD213, Kanda, Accra, GhanaMarylene Wamukoya - Indepth NetworkMenard Chihana - Indepth NetworkAmelia Crampin - University of LondonAlison Price - University of LondonValerie Delaunay - Institut de Recherche pour le DéveloppementAldiouma Diallo - Institut de Recherche pour le DéveloppementLaetitia Douillot - Institut de Recherche pour le DéveloppementCheikh Sokhna - Institut de Recherche pour le DéveloppementF. Xavier Gomez-Olive - University of the WitwatersrandPaul Mee - University of the WitwatersrandStephen M. Tollman - Institut de Recherche pour le DéveloppementKobus Herbst - University of KwaZulu-NatalJoel Mossong - University of KwaZulu-NatalNguyen T. K. Chuc - Hanoi Medical UniversitySamuelina S. Arthur - INDEPTH Network, POB KD213, Kanda, Accra, GhanaOsman A. Sankoh - University of the WitwatersrandPeter Byass - University of the Witwatersrand
- Publication Details
- Global health action, v 7(1), pp 25370-25370
- Publisher
- Taylor & Francis
- Number of pages
- 11
- Grant note
- Wellcome Trust William & Flora Hewlett Foundation Ethiopian Public Health Association (EPHA) Bill and Melinda Gates Foundation (USA); Bill & Melinda Gates Foundation KEMRI CDC; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA WT081993MA; 084538; 091758 / Wellcome Trust Rockefeller Foundation (USA) 2006-1512 / Forte, the Swedish Research Council for Health, Working Life and Welfare Mekelle University UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Comic Relief (UK) Swedish International Development Cooperation Agency (SIDA); Norwegian Agency for Development Cooperation - NORAD Sida MC_UP_A900_1123 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 5U22/PS022179_10 / EPHA-CDC US Centers for Disease Control and Prevention (CDC); United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA William and Flora Hewlett Foundation (USA) 058893/Z/99/A; 069683/Z/02/Z; 085477/Z/08/Z / Wellcome Trust, UK; Wellcome Trust 295168 / European Community Marie Curie Actions IPHTRE project
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Community Health and Prevention
- Web of Science ID
- WOS:000209735300001
- Scopus ID
- 2-s2.0-84994876171
- Other Identifier
- 991020531859304721
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- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health