Journal article
HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE
Neuro-oncology (Charlottesville, Va.), v 21(Supplement_6), pp vi112-vi112
11 Nov 2019
Abstract
Abstract
INTRODUCTION
Vestibular schwannomas (VS) are known to be slow-growing lesions that can present significant issues for patients. Here, we sought to better understand their outcomes and risks for recurrence.
METHODS
We retrospectively reviewed clinical outcomes data for patients who had VS tumor that underwent whole-exome sequencing after surgical resection between 2015 and 2018. The association between any two categorical variables was investigated using Fisher’s exact test. The mean of a continuous variable was compared between groups using either a two-tailed t-test or ANOVA.
RESULTS
Forty patients met our inclusion criteria. Interestingly, men were more likely than women to experience recurrence (p = 0.05). In accordance with previous research demonstrating a significant association between NF2 and bilateral vestibular schwannomas, most VS were NF2-mutants, with only four being were non-NF2. Pre-operative tumor size significantly correlated with progression-free survival time from surgical resection to recurrence, such that larger tumors were more likely to recur slower post-operatively (p = 0.043). There appeared to be no significant association between the extent of surgical resection (EOR) and recurrence (p = 0.653). In addition, there was no significant difference in post-operative complications or clinical outcomes, including EOR and facial nerve function, between different surgical approaches (p > 0.30). Patients with pre-operative intra-tumoral hemorrhage were more likely to have smaller tumors, suggesting they present more acutely (p = 0.119). Finally, patients with NF2-mutated VS had a longer time from original diagnosis to surgery than patients who had non-NF2 VS mutants (p = 0.041).
CONCLUSIONS
Surgery for VS offers good clinical outcomes overall with low recurrence rates, regardless of prior treatment. Though not related to Ki67, larger tumors appear to confer a slower growth potential and lower risk of recurrence over time.
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Details
- Title
- HOUT-03. CLINICAL OUTCOMES OF PATIENTS WITH VESTIBULAR SCHWANNOMAS: THE RELEVANCE OF TUMOR SIZE AND RECURRENCE
- Creators
- Amy Zhao - Yale UniversityElena Fomchenko - Yale UniversityEvgeniya Tyrtova - Yale UniversityAnita Huttner - Yale UniversityYawei Zhang - Yale UniversityRobert Fulbright - Yale UniversityE Zeynep Erson-Omay - Yale School of MedicineLan Jin - Yale UniversityJennifer Moliterno - Yale University
- Publication Details
- Neuro-oncology (Charlottesville, Va.), v 21(Supplement_6), pp vi112-vi112
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Other Identifier
- 991022004872704721