Journal article
HTLV-I-Induced Lymphoma Mimicking Hodgkin’s Disease. Diagnosis by Polymerase Chain Reaction Amplification of Specific HTLV-I Sequences in Tumor DNA
Blood, v 71(4), pp 1027-1032
Apr 1988
PMID: 2895676
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A patient with a localized HTLV-l-associated lymphoproli-ferative disease that was misdiagnosed as Hodgkin's disease is presented. The patient's serum was negative for HTLV-I antibodies by enzyme-linked immunosorbent assay (ELISA), Western blot, and radioimmunoprecipitation. Tumor tissue DNA was negative for HTLV-I by Southern blotting but was positive for distinct HTLV-I sequences when subjected to DNA amplification using the polymerase chain reaction. We conclude that the clinical and pathologic diagnosis of HTLV-l-related lymphoma can be difficult and can be confused with Hodgkin's disease. Extremely sensitive molecular biological techniques may be required to establish a diagnosis of HTLV-I-induced lymphoma.
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Details
- Title
- HTLV-I-Induced Lymphoma Mimicking Hodgkin’s Disease. Diagnosis by Polymerase Chain Reaction Amplification of Specific HTLV-I Sequences in Tumor DNA
- Creators
- David B. Duggan - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Garth D. Ehrlich - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Frederick P. Davey - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Shirley Kwok - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.John Sninsky - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Jack Goldberg - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Leon Baltrucki - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.Bernard J. Poiesz - Division of Hematology/Oncology, SUNY Health Science Center, Syracuse 13210.
- Publication Details
- Blood, v 71(4), pp 1027-1032
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1988M985300031
- Scopus ID
- 2-s2.0-0023897850
- Other Identifier
- 991019196663704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology