Journal article
Habitual Behavior Is Mediated by a Shift in Response-Outcome Encoding by Infralimbic Cortex
eNeuro, v 4(6), pENEURO.0337-17.2017
Nov 2017
PMID: 29302616
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability to flexibly switch between goal-directed actions and habits is critical for adaptive behavior. The infralimbic prefrontal cortex (IfL-C) has been consistently identified as a crucial structure for the regulation of response strategies. To investigate the role of the IfL-C, the present study employed two validated reinforcement schedules that either promote habits or goal-directed actions in mice. The results reveal that information about action-outcome relationships is differentially encoded in the IfL-C during actions and habits as evidenced by encoding of behavioral outcomes during goal-directed actions that is lost during habits. Optogenetic inhibition of the IfL-C selectively at press during habitual behavior (when firing rates are reduced during unreinforced goal-directed actions) resulted in restoration of sensitivity to change of action-outcome contingency. These results reveal a novel functional mechanism by which IfL-C promotes habitual behavior, and provide insight into strategies for the treatment and prevention of pathological, inflexible behavior common in neuropsychiatric illness.
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Details
- Title
- Habitual Behavior Is Mediated by a Shift in Response-Outcome Encoding by Infralimbic Cortex
- Creators
- Jacqueline M Barker - Medical University of South CarolinaW Bailey Glen - Medical University of South CarolinaDavid N Linsenbardt - University of IndianapolisChristopher C Lapish - University of IndianapolisL Judson Chandler - Medical University of South Carolina
- Publication Details
- eNeuro, v 4(6), pENEURO.0337-17.2017
- Publisher
- Society for Neuroscience
- Grant note
- P60 AA007611 / NIAAA NIH HHS P50 AA010761 / NIAAA NIH HHS R01 AA023786 / NIAAA NIH HHS K99 AA024499 / NIAAA NIH HHS R01 AA022701 / NIAAA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000419509400002
- Scopus ID
- 2-s2.0-85040988114
- Other Identifier
- 991020099278004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences