Journal article
Haemolytic and nonhaemolytic neonatal jaundice have different risk factorprofiles
ACTA PAEDIATRICA, v 105(12), pp 1444-1450
01 Dec 2016
PMID: 27173507
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aim: This study examined maternal and pregnancy risk factors for haemolytic and nonhaemolytic neonatal jaundice in a large population-based cohort study.
Methods: We conducted a cohort study of 1019220 singleton live births from the Swedish medical birth register from 1987 to 2002, using information on neonatal jaundice and maternal and pregnancy characteristics. Diagnoses of gestational hypertensive disorders were obtained by linkage to the national inpatient register. Multivariate logistic regression analysis provided odds ratios for the risk factors of both forms of jaundice.
Results: A total of 6057 (0.6%) births were affected by haemolytic jaundice and 36869 (3.6%) by nonhaemolytic jaundice. The strongest risk factors for haemolytic jaundice were maternal alloimmunisation, blood group O and neonatal jaundice in older siblings. For nonhaemolytic jaundice, the strongest risk factors were preterm birth, neonatal jaundice in older siblings, maternal origin from East or South-East Asia and maternal obesity. We estimated that 13% of haemolytic jaundice was attributable to alloimmunisation and 39% of nonhaemolytic jaundice was attributable to preterm birth.
Conclusion: Haemolytic and nonhaemolytic neonatal jaundice had different risk factor profiles. Interventions to reduce maternal alloimmunisation, preterm birth and maternal obesity may lower the prevalence of neonatal jaundice and the risk of consequent neurological complications.
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Details
- Title
- Haemolytic and nonhaemolytic neonatal jaundice have different risk factorprofiles
- Creators
- Brian K. Lee - Drexel UniversityIsabelle Le Ray - Karolinska InstituteJi Yu Sun - Karolinska InstituteAgneta Wikman - Karolinska University HospitalMarie Reilly - Karolinska InstituteStefan Johansson - Sachs' Children and Youth Hospital
- Publication Details
- ACTA PAEDIATRICA, v 105(12), pp 1444-1450
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- 60521601; C0320601 / Swedish Research Council; European Commission
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000387793000029
- Scopus ID
- 2-s2.0-85016274810
- Other Identifier
- 991019168757604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics