Journal article
Hagfish intestinal antimicrobial peptides are ancient cathelicidins
Peptides (New York, N.Y. : 1980), v 24(11), pp 1655-1667
Nov 2003
PMID: 15019197
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Three potent broad-spectrum antimicrobial peptides (HFIAP-1, -2, and -3) isolated from intestinal tissues of Myxine glutinosa (Atlantic hagfish) are identified as ancient members of the cathelicidin family of antimicrobial peptides, hitherto known only from mammals. In situ hybridization reveals that HFIAPs are produced in nests of myeloid cells within the loose connective tissue of the gut wall, a tissue reminiscent of both gut-associated lymphoid tissue (GALT) and vertebrate spleen. We suggest that this tissue organization provides local defense of the hagfish gastrointestinal tract via innate immunity and possibly served as the architectural plan upon which the adaptive immune system evolved.
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Details
- Title
- Hagfish intestinal antimicrobial peptides are ancient cathelicidins
- Creators
- Thomas Uzzell - Drexel UniversityEthan D Stolzenberg - University of PennsylvaniaAnn E Shinnar - Barnard CollegeMichael Zasloff - Georgetown University Medical Center
- Publication Details
- Peptides (New York, N.Y. : 1980), v 24(11), pp 1655-1667
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000189110700003
- Scopus ID
- 2-s2.0-1042290514
- Other Identifier
- 991019350685504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy