Journal article
Hair cell morphological patterns and polarity organization in the sea lamprey vestibular cristae
Anatomical record (Hoboken, N.J. : 2007), v 306(8), pp 2170-2184
Aug 2023
PMID: 36651665
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The inner ear of the sea lamprey was examined by scanning electron microscopy, antibody labeling with tubulin, Myo7a, Spectrin, and Phalloidin stain to elucidate the canal cristae organization and the morphology and polarity of the hair cells. We characterized the hair cell stereocilia bundles and their morphological polarity with respect to the kinocilia. We identified three types of hair cells. In Type 1 hair cells, the kinocilia were slightly longer than the tallest stereocilia. This type was located along the medial bank of the crista and their polarity, based on kinocilia location, was uniformly pointed ampullipetally. Type 2 hair cells that had kinocilia that were much longer than the stereocilia, were most abundant in the central region of the crista. This type of hair cell displayed variable polarity. Type 3 hair cells had extremely long kinocilia (~40-50 μm long) and with extremely short stereocilia. They were mostly located in the lateral zone crista and displayed ampullipetal polarity. Myo7a and tubulin antibodies revealed that hair cells and vestibular afferents are distributed across the canal cristae in the lamprey, covering the area of cruciate eminence; a feature that is absent in more derived vertebrates. Spectrin shows hair cells of varying polarities in the central zone. In this zone, some cells followed the main polarity vector (lateral) like those in medial and lateral zones, whereas other cells displayed polarities that carried up to 40° from the main polarity vector.
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Details
- Title
- Hair cell morphological patterns and polarity organization in the sea lamprey vestibular cristae
- Creators
- Bernd Fritzsch - University of IowaJennifer Kersigo - University of IowaKassidy Rejent - University of ToledoWesley Gherman - University of ToledoPatrick W Frank - University of ToledoDavid R Giovannucci - University of ToledoAdel Maklad - University of Toledo
- Publication Details
- Anatomical record (Hoboken, N.J. : 2007), v 306(8), pp 2170-2184
- Publisher
- Wiley
- Grant note
- R01 AG060504 / NIA NIH HHS R01 DC012060-01 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000918347400001
- Scopus ID
- 2-s2.0-85146967861
- Other Identifier
- 991021900206804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anatomy & Morphology