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Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends
Journal article   Open access   Peer reviewed

Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

Michel Sabe, Toby Pillinger, Stefan Kaiser, Chaomei Chen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Stefan Leucht, Christoph U. Correll and Marco Solmi
Neuroscience and biobehavioral reviews, v 136, 104608
May 2022
DOI: https://doi.org/10.1016/j.neubiorev.2022.104608
PMID: 35303594
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.neubiorev.2022.104608View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

CiteSpace Evidence synthesis Meta-analysis Psychosis Scientometric Systematic review ESI Highly Cited Paper (Incites)
Changes over 50 years of research on antipsychotics in schizophrenia have occurred. A scientometric synthesis of such changes over time and a measure of researchers' networks and scientific productivity is currently lacking. We searched Web of Science Core Collection from inception until November 5, 2021, using the appropriate key. Our primary objective was to conduct systematic mapping with CiteSpace to show how clusters of keywords have evolved over time and obtain clusters’ structure and credibility. Our secondary objective was to measure research network performance (countries, institutions, and authors) using CiteSpace, VOSviewer, and Bibliometrix. We included 32,240 studies published between 1955 and 2021. The co-cited reference network identified 25 clusters with a well-structured network (Q=0.8166) and highly credible clustering (S=0.91). The main trends of research were: 1) antipsychotic efficacy; 2) cognition in schizophrenia; 3) side effects of antipsychotics. Last five years research trends were: ‘ultra-resistance schizophrenia’ (S=0.925), ‘efficacy/dose-response’ (S=0.775), ‘evidence-synthesis’ (S=0.737), ‘real-world effectiveness’ (S=0.794), ‘cannabidiol’ (S=0.989), and ‘gut microbiome’ (S=0.842). These results can inform funding agencies and research groups' future directions. •First broad scientometric analysis over 50 years of research on antipsychotics.•This work provides insight on evolution of research trends on antipsychotics in schizophrenia.•Latest trends were safety/long-acting injectable, evidence synthesis and real-world evidence.•USA is dominating the research field, and China is developing rapidly.•Influence of authors, institutions, countries and latest research trends were identified.

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14 Record Views
180 citations in Web of Science
160 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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InCites Highlights

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Highly Cited Paper 
Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Behavioral Sciences
Neurosciences
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