Journal article
Halothane-caffeine contracture testing in neuromuscular diseases
Muscle & nerve, v 11(5), pp 453-457
May 1988
PMID: 3374516
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The association of malignant hyperthermia (MH) with neuromuscular disorders has been recognized since 1970. These disorders include central core disease, Duchenne muscular dystrophy, myotonia congenita, myotonic dystrophy, nonspecific myopathies, and King–Denborough syndrome. In order to assess the anesthetic risk of MH in the neuromuscular population, we performed halothane and caffeine contracture testing for MH susceptibility on biopsied muscle removed from 25 consecutive neuromuscular patients during diagnostic evaluation. Positive contracture tests were found in 7 to 18 patients with myopathic disorders and 3 to 7 patients with neurogenic disorders. Two of our patients had anesthetic events suggesting MH. These findings suggest that myopathic and neuropathic disorders share pathogenic mechanisms with MH, resulting in positive contracture tests and possibly leading to clinical events during anesthesia. Although there is controversy regarding the interpretation of a positive contracture test, contracture testing remains the most widely accepted test for MH susceptibility. Thus, a variety of neuromuscular disorders may be associated with MH susceptibility, and caution should be exercised during anesthesia in this group of patients.
Metrics
Details
- Title
- Halothane-caffeine contracture testing in neuromuscular diseases
- Creators
- Terry D. Heiman-Patterson - Hahnemann University HospitalHenry Rosenberg - Hahnemann University HospitalJeffrey E. Fletcher - Hahnemann University HospitalAlbert J. Tahmaoush - Hahnemann University Hospital
- Publication Details
- Muscle & nerve, v 11(5), pp 453-457
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:A1988N166100006
- Scopus ID
- 2-s2.0-0023878636
- Other Identifier
- 991019184060704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Neurosciences