Journal article
Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden
JOURNAL OF ALZHEIMERS DISEASE, v 91(3), p999
2023
PMID: 36530088
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Strength and mobility are essential for activities of daily living. With aging, weaker handgrip strength, mobility, and asymmetry predict poorer cognition. We therefore sought to quantify the relationship between handgrip metrics and volumes quantified on brain magnetic resonance imaging (MRI). Objective: To model the relationships between handgrip strength, mobility, and MRI volumetry. Methods: We selected 38 participants with Alzheimer's disease dementia: biomarker evidence of amyloidosis and impaired cognition. Handgrip strength on dominant and non-dominant hands was measured with a hand dynamometer. Handgrip asymmetry was calculated. Two-minute walk test (2MWT) mobility evaluation was combined with handgrip strength to identify non-frail versus frail persons. Brain MRI volumes were quantified with Neuroreader. Multiple regression adjusting for age, sex, education, handedness, body mass index, and head size modeled handgrip strength, asymmetry and 2MWT with brain volumes. We modeled non-frail versus frail status relationships with brain structures by analysis of covariance. Results: Higher non-dominant handgrip strengthwas associated with larger volumes in the hippocampus (p = 0.02). Dominant handgrip strength was related to higher frontal lobe volumes (p = 0.02). Higher 2MWT scores were associated with larger hippocampal (p = 0.04), frontal (p = 0.01), temporal (p = 0.03), parietal (p = 0.009), and occipital lobe (p = 0.005) volumes. Frailty was associated with reduced frontal, temporal, and parietal lobe volumes. Conclusion: Greater handgrip strength and mobility were related to larger hippocampal and lobar brain volumes. Interventions focused on improving handgrip strength and mobility may seek to include quantified brain volumes on MR imaging as endpoints.
Metrics
Details
- Title
- Handgrip Strength Is Related to Hippocampal and Lobar Brain Volumes in a Cohort of Cognitively Impaired Older Adults with Confirmed Amyloid Burden
- Publication Details
- JOURNAL OF ALZHEIMERS DISEASE, v 91(3), p999
- Publisher
- IOS PRESS; AMSTERDAM
- Grant note
- We thank the patients and families that participated in this research, without which this work would not be possible. We would like to acknowledge Dr. Sarah McEwen for her assistance setting up the trial from which the study subjects were drawn for this report. This work was supported by Providence St. Joseph Health, Seattle, WA [Alzheimer's Translational Pillar (ATP)]; Saint John's Health Center Foundation; Pacific Neuroscience Institute and Foundation, including the generous support of the Will and Cary Singleton as well as the McLoughlin family; and the National Institutes of Health [U01AG046139, RF1AG072637, RF1AG057443, U01AG061359, R01AG062514, R21AG061494]. Dr. Raji is supported in his research by funding from the National Institutes of Health [1RF1AG072637, R01AG070883].
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000925066900009
- Scopus ID
- 2-s2.0-85147457555
- Other Identifier
- 991021861213004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences