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Journal article
Harmaline-induced impairment of Pavlovian conditioning in the rabbit
The Journal of neuroscience, v 13(4), pp 1616-1623
01 Apr 1993
PMID: 8463839
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Abstract
In this study we examined the effects of harmaline on Pavlovian conditioning of the rabbit's nictitating membrane response. The acquisition of conditioned responses was determined during a single session consisting of 120 pairings of a tone-conditioned stimulus with a corneal air puff unconditioned stimulus. Harmaline severely retarded (5 mg/kg) or completely blocked (10 and 20 mg/kg) acquisition of conditioned responses. The blocked or retarded acquisition of conditioned responses could still be detected when the rabbits were tested 2 d after cessation of drug injections, suggesting that harmaline was affecting acquisition and not the motoric expression of conditioned responses. Control experiments established that harmaline (5 mg/kg) did not affect (1) baseline levels of responding, (2) the level of non-associative responding to the conditioned stimulus, (3) the amplitude or any of the temporal characteristics of the unconditioned response, (4) the development of habituation to the unconditioned stimulus, and (5) the threshold of the unconditioned stimulus for eliciting the unconditioned response. However, harmaline did produce a 12 dB increase in the intensity threshold of the conditioned stimulus for eliciting conditioned responses. We concluded that the primary effect of harmaline was to impair stimulus processing within brainstem circuits such as to reduce the excitatory properties of the conditioned stimulus, thus retarding its entry into associative learning. The results were discussed with respect to the possible role of the inferior olive in associative learning.
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Details
- Title
- Harmaline-induced impairment of Pavlovian conditioning in the rabbit
- Creators
- J A Harvey - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)A G Romano - Drexel University, Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Publication Details
- The Journal of neuroscience, v 13(4), pp 1616-1623
- Publisher
- Society for Neuroscience
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program; Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:A1993KV71100025
- Scopus ID
- 2-s2.0-0027531768
- Other Identifier
- 991014878084304721
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- Web of Science research areas
- Neurosciences