Journal article
Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
Nature reviews. Immunology, v 24(1), pp 18-32
01 Jan 2024
PMID: 37402992
Abstract
This Review describes recent advances in the field of 3D in vitro modelling technologies that enable a better understanding of immune cell and tumour cell interactions in the tumour microenvironment. The authors explain how such systems can be used to assess the efficacy of novel immunotherapies, including personalized immunotherapies, for patients with cancer.
In vitro 3D models are advanced biological tools that have been established to overcome the shortcomings of oversimplified 2D cultures and mouse models. Various in vitro 3D immuno-oncology models have been developed to mimic and recapitulate the cancer-immunity cycle, evaluate immunotherapy regimens, and explore options for optimizing current immunotherapies, including for individual patient tumours. Here, we review recent developments in this field. We focus, first, on the limitations of existing immunotherapies for solid tumours, secondly, on how in vitro 3D immuno-oncology models are established using various technologies - including scaffolds, organoids, microfluidics and 3D bioprinting - and thirdly, on the applications of these 3D models for comprehending the cancer-immunity cycle as well as for assessing and improving immunotherapies for solid tumours.
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Details
- Title
- Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies
- Creators
- Zhenzhen Zhou - Tsinghua UniversityYuan Pang - Tsinghua UniversityJingyuan Ji - Tsinghua UniversityJianyu He - Tsinghua UniversityTiankun Liu - Tsinghua UniversityLiliang Ouyang - Tsinghua UniversityWen Zhang - Chinese Academy of Medical Sciences & Peking Union Medical CollegeXue-Li Zhang - Shanghai Jiao Tong UniversityZhi-Gang Zhang - Shanghai Jiao Tong UniversityKaitai Zhang - Chinese Academy of Medical Sciences & Peking Union Medical CollegeWei Sun (Corresponding Author) - Ministry of Education
- Publication Details
- Nature reviews. Immunology, v 24(1), pp 18-32
- Publisher
- Nature Publishing
- Number of pages
- 15
- Grant note
- 20220484075 / Beijing Nova Program; Beijing Municipal Science & Technology Commission 52175273; 82072837; 52211540006 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 3212007 / Beijing Natural Science Foundation 20213080030; 2022ZLB004 / Tsinghua University Initiative Scientific Research Program; Tsinghua University B17026 / 111 Project; Ministry of Education, China - 111 Project 2018YFA0703004 / National Key Research and Development Program of China; National Key Research & Development Program of China; National Key Technology R&D Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]; Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:001023615800003
- Scopus ID
- 2-s2.0-85164038322
- Other Identifier
- 991022202512904721